不同月龄大鼠单侧大脑中动脉闭塞对心肌的影响  

The effects of cerebral ischemia on myocardium in different month-age rats

作　　者：马宁[1] 张北奇[1] 陈素清 于占久[1] 董力[1] 张硕立[1] 周锡英[1] 

机构地区：[1]河北省医学科学院

出　　处：《中国病理生理杂志》1994年第4期406-408,共3页Chinese Journal of Pathophysiology

摘　　要：３个月及１８个月大鼠各１０只闭塞单侧大脑中动脉后３小时其心肌组织病理学、超微结构，Ｎ－乙酰－β－Ｄ氨基葡萄糖苷酶活性（ＮＡＧａｓｅ）、超氧化物歧化酶活性（ＳＯＤ）和过氧化脂质代谢产物丙二醛含量（ＭＤＡ）、外周血血小板聚集度等变化的比较发现：老年大鼠的心肌改变程度比成年大鼠明显，表现为心肌组织点状坏死灶，线粒体肿胀，部分嵴排列不规则，ＮＡＧ＿ａｓｅ活性增高，ＳＯＤ水平下降，ＭＤＡ含量升高，血小板解聚度降低等。提示老年大鼠脑卒中发生后可致心肌组织损伤。The aim was to confirm the effects of cerebral ischemia on myocardium in different month-age rats.40 rats each in 18-24 months age and 3-4 months-age group were divided further into the cerebral ischemic group and control group. The cerebral ische- mic model were established by catheterization of left middle cerebral artery. Three hours after cerebral isckemia,pathology,SOD,MDA,NAGase,platelet gather forces and cerebral ischemic sizes were examined.The results showed that after cerebral ischemia,all index showed unusual changes. But the degree of damage in the old age group was far more serious than that of the adult group.It appeared that pathologic damage severes,SOD level decreased,MDA content increased,NAGase activiy going up,platelet releasing forces redu-ced and so on. It was suggested that after cerebral ischemia the myocardium damages in old rats was more serious.

关 键 词：脑缺血 心肌 游离基类 

分 类 号：R363.273[医药卫生—病理学]