LHRH药代动力学试验  

Study on pharmacokinetics of luteinizing hormone-releasing Hormone in rat

作　　者：扈正桃[1] 杨芳炬[1] 黄继华[1] 韩旭[1] 胡朝阳[1] 邹毅[1] 

机构地区：[1]四川大学华西医学中心基础与法医学院,成都610041

出　　处：《四川生理科学杂志》2005年第1期9-11,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:研究黄体激素释放激素(Luteinizinghormone releasinghormone,LHRH)在大鼠体内的药动学规律。方法:用氯胺T法将125I标记到LHRH分子上(放化纯度96.2%),14只SD大鼠随机分为大剂量、小剂量组,每组7只,分别肌肉注射125I LHRH(小剂量组0.5mg.kg,大剂量组1.00mg.kg),给药后在21个不同时间点逐一取各鼠尾动脉血做放射性测定。结果:大鼠试验结果显示,大剂量组t1/2平均为67.83±20.84h;小剂量组半衰期平均为64.68±22.90h。LHRH的药—时曲线符合二室模型,大剂量LHRH和小剂量LHRH的主要药动学指标差别不大。结论:LHRH在大鼠体内的消除模式为二室模型,为一级动力学消除。Objective: to study the phamacokinetics of LHRH in rat. Method: the concentration of LHRH tagged with ^(125)I in plasma were measured with dosemitry after LHRH was injected into SD rat through musculature. Result: the concentration ^(125)I time curves of LHRH were fitted to the two-compartment open modal. The t_(1/2) were 65.55±14.91h; 64.12±24.07h, respectively. Conclusion: the result of the study provides a theoretical basis for trials.the metsbolization of LHRH in rats were fitted to two-compartment model in pharmacokinetic.

关 键 词：LHRH 力学试验 黄体激素释放激素 ^125I标记 药代 二室模型 放射性测定 一级动力学 大剂量 小剂量 放化纯度 氯胺T法 SD大鼠 肌肉注射 不同时间 试验结果 药动学 动脉血 半衰期 体内 平均 

分 类 号：R96[医药卫生—药理学]