代谢酶基因、DNA修复基因多态性与食管癌关系的研究进展  

Progress in the Researches on the Association between Genetic Polymorphisms of Metabolismase,DNA Repair Gene and Susceptibility to Esophageal Cancer

作　　者：谢莹[1] 孙桂菊[1] 

机构地区：[1]东南大学公共卫生学院营养与食品卫生系,江苏南京210009

出　　处：《环境与职业医学》2005年第2期172-175,共4页Journal of Environmental and Occupational Medicine

摘　　要：食管癌的发病机制尚未完全阐明,值得关注的是遗传因素在食管癌发生中所起的作用。本文介绍了相关的一些基因的研究进展,包括参与致癌物代谢的相关基因(CYP、GST、NAT、ALDH2 )和参与DNA损伤修复的相关基因(XR CC1、MGMT、hOGG1) ,探讨它们的多态性与食管癌易感性的关系。The pathogenesis of esophageal cancer has not been clarified yet.What deserves our attention is genetic factors may play a role in the mechanisms of EC.The investigation progress of some related genes including metabolismase genes involved in carcinogen metabolism(CYP,GST,NAT,ALDH2) and DNA damage-repairing genes(XRCC1,MGMT,hOGG1) were introduced in this article so as to discuss the relationship between their polymorphisms and susceptibility to esophageal cancer.

关 键 词：食管癌 代谢酶基因 基因多态性 DNA修复 DNA损伤修复 相关基因 致癌物代谢 发病机制 遗传因素 MGMT 癌易感性 癌发生 GST NAT 

分 类 号：R735.1[医药卫生—肿瘤] R734.202[医药卫生—临床医学]