地榆升白片预防乳腺癌患者新辅助化疗后外周血细胞下降的临床研究  

Clinical study on diyushengbai tablet to prevent myelosuppression of patients with breast cancer by neoadjuvant chemotherapy

作　　者：李洪胜 王远东 何伟星 洪健 阎冰川 

机构地区：[1]广州市肿瘤医院胸外科,广东广州510095 [2]广州市肿瘤医院中医科,广东广州510095

出　　处：《中国基层医药》2005年第4期397-398,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　观察地榆升白片对乳腺癌新辅助化疗后外周血象的影响。方法　6 9例乳腺癌患者分为观察组和对照组,两组术前接受CAF方案化疗2个疗程,化疗后均给予重组人粒细胞集落刺激因子(G CSF ,商品名:瑞白)治疗。末次化疗后2～3周患者血象恢复正常后接受乳腺癌改良根治术。观察组加服地榆升白片。观察两组外周血象变化及瑞白用量等指标。结果　观察组Ⅲ度及Ⅳ度骨髓抑制发生率12 . 5 % ,显著低于对照组的4 0 . 5 % (χ2 =3 95 ,P <0 . 0 5 ) ;观察组外周血WBC、PLT、Hb治疗后与治疗前差异无显著意义(P>0 . 0 5 ) ,对照组外周血WBC、PLT、Hb治疗后较治疗前明显下降,其中PLT差异有显著意义(P <0 . 0 5 ) ;观察组、对照组人均瑞白(10 0 μg)用量分别为(2 . 12±0 . 6 4 )支和(2 . 5 2±0 86 )支,差异有显著意义(t=2 16 ,P<0 . 0 5 )。结论　地榆升白片可预防乳腺癌化疗的骨髓抑制作用,提高PLT水平,降低WBC下降幅度,减少升白药的用量,值得推广。Objective To evaluate the effect of diyushengbai tablet on the hemogram of the patients with neoadjuvant chemotherapy.Methods Patients with breast cancer were divided into two groups.All patients accepted two courses chemotherapy with CAF before surgery.The test group consisted of 32 patients treated with a combination of diyushengbai tablet and rhG-CSF,the control group was comprised of 37 patients treated with G-CSF.Patients were evaluated to white blood cell(WBC) hemoglobin(Hb) and blood plates(PLT),as well as drug dose of rhG-CSF(recombinant human granulocyte colony stimulating factor).Results The means of WBC,Hb and PLT of the patients were slightly lower than that before treatment in the test group,but there was no significant difference existed between them.In the control group,the means of them were lower than that before treatment.There was significant difference between them about PLT(P<0.05),and there was no significant difference existed between them for WBC and Hb(P>0.05).There were 4 patients occurred grade 3 and grade 4 neutropenia in the test group,and 15 patients in the control group.There was significant difference between them(P<0.05).The means of used dose of rhG-CSF was (2.12±0.64)(filgrastin 100μg) in the test group,and (2.52±0.86) in the control group.There was statistical difference between the two groups(P<0.05).Conclusion The results suggest that diyushengbai tablet be effective to prevent myelosuppression and raise the level of hemocyte of the patients treated with chemotherapy.

关 键 词：地榆升白片 预防 乳腺癌 外周血细胞 临床研究 化疗 

分 类 号：R737.9[医药卫生—肿瘤]