p63和CK5/6在鳞癌组织中的表达及其鉴别诊断价值  

p63 and cytokeratin 5/6 expression and its value of differential diagnosis in squamous carcinomas

作　　者：肖宁新[1] 黄耀全[1] 石胜[2] 

机构地区：[1]江门市人民医院病理科,广东江门529050 [2]江门市人民医院检验科,广东江门529050

出　　处：《中国基层医药》2005年第4期444-445,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　探讨p6 3蛋白和细胞角蛋白(cytokeratin ,CK) 5 / 6在鳞癌组织中的表达及其鉴别诊断价值。方法　采用免疫组织化学EliVision法检测10 2例鳞癌和98例非鳞癌组织p6 3和CK5 / 6蛋白表达。结果　p6 3在鳞癌和非鳞癌组织中的阳性率分别为98% (10 0 / 10 2 )和7 1% (7/ 98) ,前者高于后者(χ2 =16 5 . 99,P <0 . 0 1) ,CK5 / 6在鳞癌和非鳞癌组织中的阳性率分别为5 9. 8% (6 1/ 10 2 )和9 2 % (9/ 98) ,前者高于后者(χ2 =5 0 . 2 9,P <0 . 0 1) ;p6 3和CK5 / 6蛋白在鳞癌和非鳞癌组织联合表达率分别为39 .2 % (40 / 10 2 )和3 .1%(3/ 98) ,前者高于后者(χ2 =38 71,P <0 . 0 1)。结论　p6 3和CK5 / 6蛋白的联合表达有助于提高低分化鳞癌的诊断准确性。Objective To explore p63 and cytokeratin 5/6 protein expression and its value of differential diagnosis in squamous carcinomas.Methods The expression of p63 and CK5/6 protein was identified by using Elivision's immunohistochemical essay in the paraffin embed tissue sections of 102 cases of squamous cell carcinomas and 98 cases of non-squamous cell carcinomas respectively.Results The positive immunohistochemical reaction of p63 protein were found in 98%(100/102) of squamous cell carcinomas and 7.1%(7/98) of non-squamous carcinomas respectively.The difference between two groups was statistically significant(χ 2=165.99,P<0.01).The positive immunohistochemical reaction of CK5/6 protein were found in 59.8%(61/102) of squamous cell carcinomas and 9 2%(9/98) of non-squamous carcinomas respectively.The difference between two groups was statistically significant(χ 2=50.29,P<0.01).The coexpression of p63 and CK5/6 protein were found in 39.2%(40/102) of squamous cell carcinomas and 3.1%(3/98) of non-squamous carcinomas respectively.The difference between two groups was statistically significant(χ 2=38.71,P<0.01).Conclusion The coexpression of p63 and CK5/6 protein redound to elevate the veracity in differential diagnosis for poor differential squamous carcinomas.

关 键 词：P63 CK5/6 鳞癌组织 表达 鉴别诊断 

分 类 号：R730.4[医药卫生—肿瘤]