Dukes'B期结直肠癌术后辅助化疗的Meta分析  

Meta-analysis of Postoperative Adjuvant Chemotherapy for Dukes' B Colorectal Carcinoma

作　　者：万相斌[1] 潘志忠[1] 陈功[1] 李力人[1] 万德森[1] 

机构地区：[1]中山大学肿瘤防治中心腹科,广东广州510060

出　　处：《癌症》2005年第5期600-604,共5页Chinese Journal of Cancer

摘　　要：背景与目的:Dukes'B期结直肠癌根治性手术后是否需要辅助化疗,各研究报道不一,本研究利用M eta分析探讨Dukes'B期患者术后是否需要辅助化疗。方法:收集国内外1985～2003年间关于Dukes'B期结直肠癌根治性手术后给予辅助化疗的文章,将术后辅助化疗组和单纯手术组5年生存率进行综合比较。结果:符合要求纳入分析的文献共8篇,8个随机对照试验研究,累计病例6518人。比较术后化疗组和单纯手术组的5年死亡率,其合并OR值为0.79(95%CI=0.7～0.9,P<0.01),化疗组可降低术后5年死亡率。结论:Dukes蒺B期结直肠癌术后化疗可提高5年生存率。BACKGROUND & OBJECTIVE: The necessity of adjuvant chemotherapy after radical surgery for patients with Dukes' B (stage Ⅱ) colorectal carcinoma remains controversial. This study was to evaluate effect of postoperative adjuvant chemotherapy on survival of Dukes' B patients with meta-analysis. METHODS: The results of literatures on postoperative adjuvant chemotherapy for Dukes' B patients from 1985 to 2003 were analyzed synthetically.The 5-year survival rates of postoperative adjuvant chemotherapy group and surgery alone group were compared. RESULTS: Eight published randomized controlled trails were eligible, and had 6 518 patients totally. The 5-year mortality was lower in postoperative adjuvant chemotherapy group than in surgery alone group with odds ratio (OR) of 0.79, and 95% confidence interval (CI) of 0.7-0.9, (P<0.05). CONCLUSION: Postoperative adjuvant chemotherapy could improve 5-year survival rate of Dukes' B patients.

关 键 词：结直肠肿瘤 Dukes’B期 辅助化疗 META分析 5年生存率 

分 类 号：R735.3[医药卫生—肿瘤]