肝硬化患者血清一氧化氮和食管动力关系的研究  

Study on the Relationship between Serum Nitric Oxide and Esophageal Motility in Patients with Liver Cirrhosis

作　　者：陈尼维[1] 陈维雄[1] 王如华[1] 朱金水[1] 陈金联[1] 

机构地区：[1]上海交通大学附属第六人民医院消化科,上海200233

出　　处：《中国临床医学》2005年第2期235-236,共2页Chinese Journal of Clinical Medicine

摘　　要：目的: 探讨肝硬化患者血清一氧化氮(NO)与食管动力的关系。方法: 35 例肝硬化患者(HC)和30 例健康人(HS)采用硝酸还原酶法测定血清NO含量;核素法测定食管液体通过时间和胃食管反流。结果: HC组血浆NO含量显著高于HS组(P<0.01);HC组胃食管反流发生率显著高于HS组;HC组中胃食管反流患者的NO含量显著高于无胃食管反流的患者(P<0.01),HC组的食管液体通过时间较HS组显著延长(P<0.01),但NO含量与食管通过时间无相关性(P>0.05)。结论: 肝硬化患者血浆NO含量的升高可能使食管下括约肌(LES)松弛而产生胃食管反流,但不影响食管蠕动功能。Objective: To explore the relationship between serum nitric oxide (NO) and the esophageal motility in patients with liver cirrhosis(HC).Methods: Esophageal liquid transit time and gastroesophageal reflux, and serum NO concentration were detected in 35 patients with HC and 30 healthy subjects(HS).Results: Serum NO concentration were significant different between the HC group and HS group(P<0.01);The frequency of gastroesophageal reflux in HC group was markedly higher than that in HS group;There were also significant difference between the patients without-and with gastroesophageal reflux in serum NO concentration(P<0.01);The esophageal transit time of liquid in HC group were markedly prolonged as compared with that in HS group(P<0.01),but there was no correlation between serum NO concentration and esophageal transit time(P>0.05). Conclusion:Serum NO may influence low esophageal sphincter(LES) and cause gastroesophageal reflux,but little effectiveness on esophageal peristalsis.

关 键 词：肝硬化患者 食管动力 食管液体通过时间 血清一氧化氮(NO) 胃食管反流 NO含量 食管下括约肌 食管蠕动功能 酶法测定 显著延长 患者血浆 C组 健康人 核素法 HS 发生率 相关性 

分 类 号：R575.2[医药卫生—消化系统] R57[医药卫生—内科学]