VEGF及其受体KDR在肝细胞癌中的表达  

Expression of Vascular Endothelial Growth Factor (VEGF) and Its Receptor KDR in Hepatocellular Carcinoma

作　　者：苏进根 朱上林[2] 肖家诚[3] 王天翔[2] 项明[2] 

机构地区：[1]上海市嘉定区中心医院普外科,上海201800 [2]上海第二医科大学瑞金医院普外科,上海200025 [3]上海第二医科大学瑞金医院病理科,上海200025

出　　处：《中国临床医学》2005年第2期245-247,共3页Chinese Journal of Clinical Medicine

基　　金：上海市科学技术发展资金资助(964119027)

摘　　要：目的:研究VEGF及其受体KDR蛋白在人肝细胞癌组织中表达及其意义。方法:应用免疫组化方法检测42 例人肝细胞癌及其癌周组织与10例正常肝组织标本的VEGF及KDR。结果:VEGF及KDR在肝癌组织表达明显高于癌周及正常肝组织,与门静脉内癌栓、包膜浸润密切相关(分别为P<0.05, P<0.01)。VEGF及KDR阳性表达在生存时间2 年及2 年以上组分别为23.5%(4/17)、35%(7/20),在生存时间短于2年分别为42.1%(8/19)、56.3%(9/16)(P<0.05)。结论:肝细胞癌组织中VEGF及其受体KDR的表达与浸润转移密切相关,其阳性表达有助于判断预后。Objective: To investigate the expression and clinical significances of vascular endothelial growth factor (VEGF) and its receptor KDR protein in hepatocellular carcinoma.Methods:The expression of VEGF and KDR in hepatocellular carcinoma and adjacent tissues were examined by immunohistochemistry in 42 hepatocellular carcinoma cases and as well as in normal liver tissues of 10 cases.Results: Expression of VEGF and its receptor KDR/Flk-1 were all significantly higher in HCC tissues than those in surrounding liver and normal liver tissues.Furthermore, the expression was significantly correlated with both portal vein tumorous emboli and histological capsular infiltration(P< 0.05, P< 0.01,respectively). The positive expression of VEGF and KDR were 23.5%、35% respectively in groups which survival time was to two years on larger,while 42.1%、 56.3% respectively in those less than two years(P< 0.05).Conclusion:Expression of VEGF and its receptor KDR/Flk-1 was significantly correlated with invasion and metastasis of HCC,and it was helpful to judge prognosis.

关 键 词：VEGF 受体KDR 肝细胞癌组织 免疫组化方法 门静脉内癌栓 生存时间 阳性表达 肝组织标本 人肝细胞癌 正常肝组织 癌周组织 组织表达 0.05 浸润转移 判断预后 其意义 表达及 R蛋白 相关 

分 类 号：R735.7[医药卫生—肿瘤] R734.2[医药卫生—临床医学]