杏仁核和扣带回联合毁损对MAP大鼠脑内多巴胺D_2受体的影响  

Effect of Nucleus Amygdalae and Gyrus Cinguli Lesions on Dopamine Receptor 2 in Limbic Region in Rats with Schizophrenia Produced by Methamphetamine

作　　者：刘建新[1] 王晓峰[1] 李拴德[1] 王小亚[1] 张有兵[1] 张宏兵[1] 周静[1] 刘荣[1] 

机构地区：[1]中国人民解放军第三医院全军精神病外科治疗中心,陕西宝鸡721004

出　　处：《中国临床神经外科杂志》2005年第2期121-123,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨联合毁损杏仁核和扣带回对甲基苯丙胺(M AP)大鼠脑内边缘区多巴胺D2受体表达的影响。方法40只SD大鼠随机分为对照组、M AP组、M AP+毁损组和M AP+假毁损组,每组各10只;采用经腹腔注射M AP制备精神分裂症M AP模型,立体定向-射频毁损杏仁核和扣带回,免疫组织化学ABC法观察边缘区D2受体的表达。结果与对照组和M AP+损毁组比较,M AP组及M AP+假毁损组大鼠边缘区D2受体表达有显著性差异(P<0.01);M AP+毁损组大鼠边缘区D2受体阳性细胞率与对照组比较差异无显著性(P>0.05)。结论杏仁核和扣带回的联合毁损可抑制使用M A P诱发的边缘区D2受体表达的亢进。Objective To explore the effect of nucleus amygdalae and gyrus cinguli lesions on the dopamine receptor 2 (D2) in the limbic regions in the rats with schizophrenia induced by methamphetamine (MAP). Methods Forty Sprague-Dawley rats averagely were randomly divided into four groups, i.e. control group, MAP group, MAP and lesion group, and MAP and pseudo-lesion group. Schizophrenia model was established in the rats by intraperitoneal injection of MAP. The nucleus amygdalae and gyrus cinguli were stereotactically destroyed by radio-frequency. Immunohistochemical ABC method was used for detecting the D2 in the limbic regions of the rats. Results The MAP-induced stereotyped behavior score and the rate of D2 positive cells in the limbic regions were significantly higher in MAP group and MAP and pseudo-lesion group than those in the control group and MAP and lesion group. There was insignificant difference in both the MAP-induced stereotyped behavior score and the rate of D2 positve cells of the limbic regions between the control group and MAP and lesion group. Conclusions The lesion of nucleus amygdalae and gyrus cinguli can effectively inhibit MAP-induced stereotyped behavior and an increase in D2 positive cells rate in the limbic regions induced by MAP in the rats. <

关 键 词：精神分裂症 甲基苯丙胺 杏仁核 扣带回 多巴胺D2受体 

分 类 号：R739.3[医药卫生—肿瘤] R363.21[医药卫生—临床医学]