三氟乙酰伯氨喹对鼠疟红内期原虫作用  

EFFECT OF TRIFLUOROACETOPRIMAQUINE ON ERYTHROCYTIC SCHIZONTS OF RODENT MALARIA

作　　者：叶秀玉[1] 邵葆若[1] 储言红 

机构地区：[1]中国预防医学科学院寄生虫病研究所

出　　处：《中国寄生虫学与寄生虫病杂志》1994年第3期223-224,共2页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：参照ＷＨＯ推荐的“４ｄ抑制性试验法”给药，并采用延长疗效的观察期和取血再转种的方法证明：三氟乙酰伯氨喹２０ｍｇ／ｋｇ·ｄ×４ｄ能完全清除血内的伯氏疟原虫ＡＮＫＡ株；对抗氯喹伯氏疟原虫ＮＳ系和抗咯萘啶伯氏疟原虫ＲＰ系亦显示有不同程度的抑制作用，但疗效明显较差，与用伯氨喹相似。提示，８－氨基喹啉类药物与氯喹、咯萘啶等红内期杀灭剂有一定的交叉抗性。Effect of trifluoroacetoprimaquine oxalate(M8506) and primaquine(PQ) on blood schizonts of Plasmodium berghei were determined using the method of 4 day suppressive test within extended observation period of 60 d.When mice infected with Plasmodium berghei ANKA strain were treated ig with M8506 or PQ at a same daily dose of 20 mg/kg for 4 d,the cure rates were 100% and 90% ,respectively.The two drugs also showed prominent suppressive effects on chloroquine resistant P.berghei NS line and pyronarine resistant P.berghei RP line,but the parasitemia still remained positive or all of the mice treated recrudesced,indicating the existence of cross resistance between trifluoroacetoprimaquine and other erythrocytic schizonticides,including chloroquine and pyronaridine.

关 键 词：疟原虫 伯氨喹 抗药性 M8506 

分 类 号：R978.61[医药卫生—药品]