S100A2蛋白表达与胃癌分化程度的关系研究  

Relationship of the S100A2 Protein and Differentiation of Gastric Carcinoma

作　　者：刘迎福[1] 贺修胜[1] 徐刚[1] 邓敏[1] 曾超[1] 赵帅[1] 

机构地区：[1]南华大学肿瘤研究所,湖南衡阳421001

出　　处：《南华大学学报（医学版）》2005年第1期1-3,12,共4页Journal of Nanhua University(Medical Edition)

基　　金：湖南省教育厅课题 (NO .0 1B0 16;No .97B0 95 );湖南省卫生厅课题 (NO .Y0 2 -0 69);自然科学基金课题 (N0 .0 3JJY3 0 2 9);科技厅基金课题 ( 0 2SSY40 0 4)

摘　　要：目的　研究胃癌中S1 0 0A2蛋白表达 ,并分析其与胃癌分化程度的关系。方法　采用链霉菌抗生物素蛋白 -过氧化酶 (S -P)免疫组织化学方法检测 40例胃癌组织和正常胃黏膜组织中S1 0 0A2蛋白的表达水平。结果　胃癌中S1 0 0A2蛋白表达率为 5 2 .5 0 % ( 2 1 40 ) ,而正常胃黏膜组织S1 0 0A2蛋白表达率为 1 0 0 % ( 4 0 40 ) ,S1 0 0A2蛋白在胃癌中的表达率明显低于正常胃黏膜 (P <0 .0 5 ) ;S1 0 0A2蛋白在不同分化程度胃癌中的阳性表达率分别为 :高分化组 75 .0 0 % ,中分化组 5 3.84% ,低分化组 1 8.1 8% ,表明S1 0 0A2蛋白表达与胃癌分化程度有关。结论　S1 0 0A2基因编码的产物S1 0 0A2蛋白质在胃癌中存在表达缺失或下调 ,表明S1 0 0A2蛋白表达减少与胃癌的发生发展及分化程度有关。S1 0 0A2蛋白表达的检测 。Objective To investigate the expression of S100A2 protein and analyze its relationship between differentiation of gastric carcinoma. Methods The expression of S100A2 protein was detected with streptavidin-peroxidase conjugated (S-P) immunohistochemical technique method in 40 cases of gastric carcinoma and normal gastric mucosa. Results The positive rates of S100A2 protein expression were 52.50% in gastric carcinoma and 100% in normal gastric mucosa respectively. The positive rate of S100A2 protein expression in gastric carcinoma was significantly lower than that in normal gastric mucosa (P<0.05). The positive rate of S100A2 expression were 75.00% in highly, 53.84% in moderately and 18.18% in poorly differentiated gastric carcinoma respectively, which indicated the expression of S100A2 protein was related to the degree of differentiation of gastric carcinoma. Conclusions The loss expression of S100A2 protein was in gastric carcinoma. The positive rate of S100A2 protein expression in poorly differentiation of gastric carcinoma was lower than that in highly and moderately differentiated gastric carcinoma, which indicated that the loss of expression of S100A2 protein was related to the carcinogenesis and differentiation of gastric carcinoma. S100A2 gene might play an important role in carcinogenesis of gastric carcinoma.

关 键 词：S100A2 胃癌 免疫组织化学 

分 类 号：Q786[生物学—分子生物学] R735.2[医药卫生—肿瘤]