乳腺癌血行转移与血管生成相关因子相关性研究  

Correlation between the angiogenic factors and the blood metastasis of breast cancer

作　　者：王深明[1] 朱彩霞[2] 黎志勋[3] 王劲松[1] 林颖[1] 

机构地区：[1]中山大学附属第一医院乳腺病诊治中心 [2]广东省妇幼保健院乳腺外科 [3]中山大学病理学教研室

出　　处：《中华实验外科杂志》2005年第5期524-526,共3页Chinese Journal of Experimental Surgery

摘　　要：目的探讨血管生成相关因子:癌基因HER2、缺氧诱导因子(HIF)和血管内皮细胞生长因子(VEGF)在乳腺癌组织中的表达及其与血行转移的相关性。方法应用免疫组织化学技术(SP法)检测51例乳腺浸润性导管癌组织中HER2、HIF-1α、VEGF蛋白的表达并随访其术后5年内远处血行转移的情况。结果51例乳腺浸润性导管癌组织中HER2、HIF-1a和VEGF表达均彼此相关。单因素分析显示44例乳腺浸润性导管癌中HER2、VEGF、淋巴结转移和临床肿瘤分期与癌的远处血行转移相关,HIF-1α表达与远处血行转移不相关(P>0.05)。23例淋巴结阴性乳腺癌中,仅VEGF表达与其远处血行转移密切相关(P<0.05)。结论乳腺浸润性导管癌组织中HER2可能通过HIF-1α途径调节VEGF蛋白的表达,参与乳腺癌血管的生成。VEGF表达可作为术后预测血行转移的指标之一,HER2过度表达和HIF-1α表达不能预测远处血行转移。Objective To study the expression of angiogenic factors (HER2,HIF-1α,VEGF) in breast invasive ductal carcinoma and the correlation between these factors and distal metastasis.MethodsThe immunohistochemical staining SP method was used to detect the expression of HER2,HIF-1α,VEGF in 51 cases of breast invasive ductal carcinoma.The patients were followed up for 5 years.ResultsThere wassignificant correlation among the expression of HER2,HIF-1α,VEGF in 51 cases of breast invasive ductal carcinoma.Univariate analysis showed a significant correlation between the overexpression of HER2,VEGF expression,lymph node status,clinical tumor stage and distal metastasis within the 5 years and no correlation between HIF-1α and distal metastasis in 44 cases (P> 0.05). In the 23 patients with negative lymph node status,significant correlation was only found between the VEGF expression and distal metastasis (P< 0.05). Conclusion HER2 may regulate the expression of VEGF through HIF-1α,thus involves in the angiogenesis of breast cancer.The expression of VEGF may be used as a predictor for distal metastasis in patients with breast invasive ductal carcinoma.While the overexpression of HER2 and the expression of HIF-1α can not be used as a predictor for distal metastasis in these patients.

关 键 词：血行转移 相关因子 血管生成 血管内皮细胞生长因子(VEGF) 相关性研究 VEGF表达 HIF-1α 免疫组织化学技术 乳腺浸润性导管癌 淋巴结阴性乳腺癌 VEGF蛋白 HER2 缺氧诱导因子 乳腺癌组织 单因素分析 淋巴结转移 方法应用 

分 类 号：R737.9[医药卫生—肿瘤]