慢性萎缩性胃炎患者幽门螺杆菌根除后胃黏膜G细胞数量和血清胃泌素含量的变化  

Changes of Gastric Mucosal G Cell Number and Serum Gastrin Contents after Eradication of Helicobacter pylori in Patients with Chronic Atrophic Gastritis

作　　者：范玉林[1] 杨建民[1] 罗元辉[1] 郭德玉[2] 刘广元[3] 

机构地区：[1]第三军医大学西南医院全军消化专科中心,400038 [2]第三军医大学西南医院病理研究所,400038 [3]第三军医大学西南医院核医学科,4000382

出　　处：《胃肠病学》2005年第2期93-96,共4页Chinese Journal of Gastroenterology

摘　　要：背景:幽门螺杆菌(H.pylori)感染是慢性萎缩性胃炎(CAG)最重要的致病因素,根除H.pylori能否阻止或逆转胃黏膜萎缩目前尚不清楚。目的:通过观察CAG患者H.pylori根除前后胃黏膜G细胞数量和血清胃泌素含量的变化,探讨H.pylori感染对胃黏膜G细胞数量及其分泌功能的影响。方法:60例H.pylori阳性的CAG患者进行了根除治疗,在治疗前和治疗结束3个月后分别行胃镜检查。采用免疫组织化学法和放射免疫分析法测定H.pylori根除前后胃窦黏膜G细胞数量和血清胃泌素含量。结果:31例H.pylori感染的CAG患者在根除治疗3个月后进行了复查,根除率为77.4%。G细胞数量和血清胃泌素含量随胃黏膜萎缩程度的加重而逐渐显著减少(P<0.01)。轻度萎缩组H.pylori根除后G细胞数量与治疗前相比无显著差异(P>0.05),而升高的血清胃泌素含量显著降低(P<0.01);中、重度萎缩组H.pylori根除后减少的G细胞数量显著增加(P<0.05),血清胃泌素含量呈上升趋势(P>0.05)。结论:CAG患者根除H.pylori后胃黏膜G细胞数量及其合成、分泌胃泌素的功能可出现恢复性变化,可能有助于阻断CAG的进一步发展。Background: Helicobacter pylori () infection has been regarded as the most important risk factor of chronic atrophic gastritis (CAG), but it is still unclear whether atrophic changes could be reversible or not after eradication of. Aims: To observe the changes of gastric mucosal G cell number and serum gastrin contents after eradication of in patients with CAG, so as to investigate the influence of infection on gastric mucosal G cell number and its secretory function. Methods:Sixty patients with both CAG and infection received eradication therapy. Gastroscopy was performed before and three months after the therapy, the antral mucosal specimens were taken to detect G cell number by immunohistochemistry and the serum gastrin contents were detected by radioimmunoassay. Res-ults: There were 31 patients received re-examination three months after eradication therapy. The eradication rate was 77.4%. With development of atrophy, the G cell number and serum gastrin contents were significantly decreased (P<0.01). Serum gastrin contents was significantly decreased aftereradication therapy in patients with mild atrophy (P<0.01), but gradually increased in patients with moderate or severe atrophy (P>0.05). There was no significant difference in G cell number after eradication therapy in mild atrophic gastritis (P>0.05), however its number was significantly increased in moderate or severe atrophic gastritis (P<0.05). Conclusions: G cell number of gastric mucosa and its synthetic and secretory functions tend to show convalescent changes after eradication therapy, and may help arresting the development of CAG.

关 键 词：血清胃泌素 细胞数量 幽门螺杆菌 萎缩性胃炎患者 根除后 含量 H.PYLORI感染 慢性萎缩性胃炎 放射免疫分析法 免疫组织化学法 胃黏膜萎缩程度 根除治疗 胃窦黏膜G CAG 致病因素 分泌功能 胃镜检查 上升趋势 治疗前 

分 类 号：R573.3[医药卫生—消化系统]