慢性重型肝炎患者生活质量评估及影响因素分析  

Evaluation on the quality of life in patients with chronic severe hepatitis and the influencing factors

作　　者：张南[1] 王宇明[1] 邓国宏[1] 张磊[1] 

机构地区：[1]解放军第三军医大学西南医院全军感染病研究所,重庆市400038

出　　处：《中国临床康复》2005年第11期19-21,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:测量并评价重型肝炎患者生活质量HRQOL),分析影响其生活质(量的主要相关因素。方法:记录130例慢性重性乙型肝炎患者的35项一般资料及临床资料,采用中国版生活质量SF-36表,对重型肝炎患者及100例正常对照进行生活质量评分并进行比较。对影响生活质量的因素进行单因素分析和多元逐步回归分析,筛选主要影响因素。结果:慢性重型肝炎患者组的SF-36总评分52±22及躯体角色62±27、总的健康40±16、活力43±23、社会功能56±26、情绪角色33±24、心理卫生40±19的平均评分与对照组(80±23,78±25,80±21,82±28,84±20,85±30,79±19)相比显著降低t=4.651～15.940,P(<0.001);影响慢性重型肝炎患者生活质量的主要因素是并发症、血白蛋白、血清胆红素和凝血酶原活动度。结论:慢性重型肝炎患者的生活质量显著下降,有效的治疗和护理有利于改善患者的生活质量。AIM: To measure and evaluate the health related quality of life (HRQOL) in patients with chronic severe hepatitis (CSH), and analyze the main related factors.METHODS: Totally 130 patients' 35 demographic and clinical characteristics were documented and their HRQQL were measured by using the Chinese version of Short Form 36 (SF 36). The HRQQL scores of the CSH patients were compared with those of 100 normal controls. Single factor analysis and multiple stepwise regression analysis were applied to evaluate the related factors, and the main influencing factors were screened.RESULTS:The total score of SF 36 (52± 22) and mean scores of body role (62± 27), general health (40± 16), vigor (43± 23), social function (56± 26), emotional role (33± 24) and mental health (40± 19) were significantly lower in the CSH group than in the normal control group (80± 23,78± 25,80± 21,82± 28,84± 20,85± 30,79± 19) (t=4.651 to 15.940, P< 0.001). The main factors that influenced the HRQOL of CSH patients were complication, serum albumin, serum bilirubin and prothrombin activity.CONCLUSION: The HRQOL of CSH patients are remarkably decreased, effective therapy and corresponding nursing care are good for the improvement of their HRQOL.

关 键 词：肝炎 生活质量 因素分析 统计学 

分 类 号：R575.1[医药卫生—消化系统]