表皮生长因子受体及β-连环素在非小细胞肺癌组织中的表达及相关性研究  

Expression of EGFR and β-catenin in Non-small-cell Lung Cancer and its Correlationship Investigation

作　　者：柯宏刚[1] 董汉宣[1] 曹飞[1] 陈莉[2] 

机构地区：[1]南通大学附属医院,226001 [2]南通大学病理解剖研究所,226001

出　　处：《实用癌症杂志》2005年第1期65-67,共3页The Practical Journal of Cancer

摘　　要：目的　探讨表皮生长因子受体(EGFR )和β-连环素(βcatenin)在非小细胞肺癌(NSCLC)中的表达及其相关性。方法　应用SABC免疫组化技术检测了5 3例NSCLC中EGFR和βcatenin的表达情况。结果　在5 3例非小细胞肺癌病理组织中,EGFR和βcatenin阳性表达率分别为67.9% (3 6/5 3 )和5 4.7% (2 9/5 3 )。在不同临床分期,有无淋巴结转移的NSCLC比较中EGFR表达有显著差异(P <0 .0 5 ) ;在不同分化程度、有无淋巴结转移的NSCLC中βcatenin表达有显著差异(P <0 .0 5 ) ,EGFR和βcatenin表达呈负相关(γ=-0 .843 6,P =0 .0 0 1)。结论　在NSCLC中,EGFR及βcatenin的表达与淋巴结转移密切相关,两者表达呈负相关,βcatenin低表达提示预后不良。Objective To investigate the expressions of β-catenin and EGFR in non-small-cell lung cancer and its correlationship.Methods SABC Immunohistochemistry method was used to detect the expressions of EGFR and β-catenin in pathological tissue sections of 53 cases of non-small-cell lung cancer.Results The positive rates of EGFR and β-catenin in 53 non-small-cell lung cancer tissue sections respectively were 67.9%(36/53)and 54.7%(29/53).There were significant differences between the patients with or without lymph-node metastasis except size of tumor,histopathological type.Only β-catenin was significant difference with differentiation(P<0.05),EGFR was significant difference with stage(P<0.05).There is negative correlation between β-catenin and EGFR(γ=-0.8436,P=0.001).Conclusion β-catenin and EGFR may Play an important tole in lymphatic metastasis of NSCLC.The negative correlation between β-catenin and EGFR might have some effect on the development of NSCLC.

关 键 词：Β-连环素 表达及 相关性研究 β-catenin 表皮生长因子受体(EGFR) 非小细胞肺癌(NSCLC) 肺癌组织 无淋巴结转移 ABC免疫组化 EGFR表达 阳性表达率 表达情况 技术检测 方法应用 病理组织 临床分期 分化程度 预后不良 负相关 

分 类 号：R734.2[医药卫生—肿瘤] R737.25[医药卫生—临床医学]