^(18)F-FDG PET与^(67)Ga全身显像对淋巴瘤分期的临床价值  

Clinical study of ^(18)F-FDG PET and ^(67)Ga imaging in patients with lymphoma

作　　者：王辉[1] 江旭峰[2] 王超[2] 李彪[2] 李培勇[2] 朱承谟[2] 

机构地区：[1]上海第二医科大学附属新华医院核医学科,200093 [2]上海第二医科大学附属瑞金医院核医学科

出　　处：《中华核医学杂志》2005年第2期100-101,共2页Chinese Journal of Nuclear Medicine

摘　　要：目的　探讨1 8F 脱氧葡萄糖(FDG)PET显像与6 7Ga全身显像对淋巴瘤患者分期的临床价值。方法　经组织病理检查诊断为淋巴瘤的2 3例患者,治疗前均行1 8F FDGPET显像与6 7Ga全身显像。PET显像为静脉注射1 8F FDG 111～185MBq(按体重2 2 2MBq kg) ,4 5～5 0min后行全身显像。6 7Ga全身显像为静脉注射370MBq6 7Ga ,4 8～72h后行前位和后位颈、胸、腹和盆腔局部全身显像。图像分析采用定性分析方法,有异常放射性摄取增高的部位为阳性病变。结果　1 8F FDGPET显像2 3例患者均阳性,共发现5 3个病灶;6 7Ga全身显像示19例( 82 6 % )阳性,发现4 4个病灶( 83 0 % )。肿瘤病灶35 8% ( 19个)在头颈部,2 0 8% ( 11个)在腹部,34 0 % ( 18个)在纵隔,9 4 % ( 5个)在盆腔。1 8F FDGPET与6 7Ga全身显像结果比较示,在19例患者中4 4个病灶两者显像结果一致。PET显像发现的5 3个病灶中,6 7Ga全身显像有9个病灶阴性,分别位于头颈部( 1个)、腹部( 4个)、盆腔( 2个)和腋窝( 2个) ,病灶直径范围为0 6～3 2cm。结论　1 8F FDGPET显像在淋巴瘤分期中明显优于6 7Ga全身显像。6Objective To study the clinical value of staging in the patients with lymphomas by comparing 18 F fluorodeoxyglucose (FDG) PET with 67 Ga whole body imaging. Methods 23 cases with lymphomas proved by the histopathology were included in this study, both 18 F FDG PET and 67 Ga whole body imaging were performed in pre and post therapy. PET imaging was performed 40～50 min after injection of 18 F FDG 111～185 MBq (2 22 MBq/kg) intravenously. The patients were in fasting state at least 4 h before imaging. 67 Ga whole body imaging was performed 48～72 h after injection of 370 MBq 67 Ga intravenously. Both images were analyzed visually. Abnormal high uptake of radioactivity in lesion site was considered as positive finding. Results 18 F FDG PET imaging demonstrated 53 positive lesions in all 23 patients (100%). However, 67 Ga whole body imaging showed 44 (83.0%) positive lesions in 19 (82.6%) patients.Of these lesions, there were 35.8% in head neck, 20 8% in abdomen, 34.0% in mediastinum and 9.4% in pelvis. Comparison between PET and 67 Ga whole body imaging showed the concordance in 19 cases with 44 lesions. In 53 lesions detected by PET imaging, 67 Ga imaging lost 9 lesions, among them 1 localized in head neck, 4 in abdomen, 2 in pelvis and 2 in axillary area, the lesion size ranged 0.6～3.2 cm. Conclusions 18 F FDG PET imaging is obviously better than 67 Ga whole body imaging in the staging of the patients with lymphomas. The diagnostic sensitivity of 67 Ga imaging would be markedly affected by its lesion size and localization.

关 键 词：^67GA 全身显像 淋巴瘤 临床价值 分期 ^18F-FDG ^18F-脱氧葡萄糖 PET显像 定性分析方法 静脉注射 检查诊断 组织病理 72h后 图像分析 肿瘤病灶 结果比较 显像结果 病灶大小 显像诊断 头颈部 患者 治疗前 PEF 盆腔 阳性 

分 类 号：R733.1[医药卫生—肿瘤]