高亲和力IgE受体介导的信号传导及其相关的抑制性受体  

Signal transportation mediated by high-affinity IgE receptors and its inhibitory receprots related

作　　者：孙仁山[1] 陈晓红[2] 冉新泽[3] 程天民[3] 

机构地区：[1]第三军医大学大坪医院皮肤科,重庆400042 [2]第三军医大学药理学教研室,重庆400042 [3]第三军医大学预防医学院复合伤研究室,创伤,烧伤与复合伤国家重点实验室,重庆400038

出　　处：《中国药理学通报》2005年第4期385-389,共5页Chinese Pharmacological Bulletin

基　　金：重庆市院士基金资助项目(No99 5591)

摘　　要：作者介绍了高亲和力IgE受体介导I型超敏反应,其活化后的信号传导通路,及其相关的抑制性受体方面的研究进展,包括FcγRIIβ、PIR B、SIRPα、CD81及MAFA。对高亲和力IgE受体介导的信号通路和其相关的抑制性受体的研究将有可能发现对抗Ⅰ型超敏反应的新靶点,从而有助于过敏相关疾病的治疗。Type I Hypersensitivity reactions are mediated by high-affinity IgE receptors (FcεR1). The research progresses on FcεR1 signaling and its related inhibitory receptors were reviewed in this article. The inhibitory receptors include FcγRIIβ,PIR-B,SIRPα,CD81 and MAFA. Studies on FcεR1 signaling and its inhibitory receptors may show some new targets that can be used to antagonize type I hypersensitivity reactions, hereby benefiting to the reactions treatment.

关 键 词：高亲和力IGE受体 信号传导 抑制性受体 

分 类 号：R-05[医药卫生] R392.11