脑内占位病变^(18)F-FET PET显像初步研究与^(18)F-FDG PET对照  

Preliminary study of ^(18)F-FET PET in detecting the brain lesions:in comparison with ^(18)F-FDG PET

作　　者：崔瑞雪[1] 程欣[1] 周前[1] 党永红[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院PET中心,北京100730

出　　处：《诊断学理论与实践》2005年第2期102-105,共4页Journal of Diagnostics Concepts & Practice

摘　　要：目的:通过O-(2-18F-氟代乙基)-L-酪氨酸(18F-FET)和18F-氟脱氧葡萄糖(18F-FDG)2种PET显像剂的对照研究,探讨18F-FET能否起到弥补18F-FDG脑显像不足的作用。方法:14例脑占位病变患者(13例胶质瘤,1例鼻咽癌放疗后出现脑占位病变)1周内行18F-FET和18F-FDG PET2次脑显像。半定量分析:用感兴趣区(ROI)法计算标准摄取值(SUV)及T/NT。结果:①12例脑胶质瘤,无论术前原发灶或术后残存/复发18F-FET显像均显示病灶,T/NT=2.34±0.70,阳性率100%;18F-FDG显像,2例摄取高于皮层,病灶显示清晰,10例病灶摄取低于正常皮层,T/NT=0.59±0.18,阳性率75%;②1例胶质瘤术后疑有复发者,18F-FET及18F-FDG均未见异常,随访10个月,临床无进展;③1例鼻咽癌患者放射治疗后左颞叶占位病变,18F-FET图像病灶呈环形,周边高摄取,中心减低,T/NT=1.86;18F-FDG显像也显示为轻度环形摄取,T/NT=0.77。结论:①18F-FET显像不论肿瘤恶性程度如何均可清晰检出病灶,优于18F-FDG;②放射治疗后坏死1例,18F-FET为高摄取,其鉴别肿瘤和放射治疗后坏死的能力尚待进一步研究。Objective To clarify the complementary role of 18F-FET in subsidizing 18F-FDG as a brain imaging agent. Methods Thirteen patients with suspected primary or recurrent gliomas and 1 patient with brain lesion after radiotherapy of nasopharyngeal cancer were studied by both 18F-FET and 18F-FDG PET within one week. The final diagnoses were proved histo-pathologically or by clinical follow-up(2-26 months). Results One primary and 11 recurrent gliomas showed high uptake of 18F-FET(T/NT=2.34±0.70) and clear tumor delineation(TP100%). However, with 18F-FDG, only 2 cases showed higher uptake and the other 10 showed lower uptake in tumor foci than that in cerebral cortex (TP75%), T/NT=0.59±0.18. Recurrence was ruled out in 1 patient by showing no uptake of both 18F-FDG and 18F-FET, and was verified by follow-up for 10 months. The patient with radiation-induced brain lesion showed increased uptake of both 18F-FDG (T/NT=0.77) and 18F-FET (T/NT=1.86). Conclusions 18F-FET is better than 18F-FDG in brain tumor detection and delineation, whose effect on differentiate the radiation necrosis from the tumor tissue needs further studies.

关 键 词：^18F-FET 步研究 ^18F-FDG显像 ^18F-氟脱氧葡萄糖 放射治疗后 脑占位病变 脑内 PET显像剂 肿瘤恶性程度 标准摄取值 半定量分析 鼻咽癌患者 对照研究 T/NT 感兴趣区 脑胶质瘤 术后残存 鉴别肿瘤 脑显像 阳性率 病灶 酪氨酸 

分 类 号：R736.4[医药卫生—肿瘤] R285.5[医药卫生—临床医学]