局部脑血流SPECT显像与其他影像对癫痫定位诊断比较的研究  

Study on location diagnosis of epilepsia by ^(99m)Tc-ECD brain SPECT rCBF imaging

作　　者：李志刚[1] 杨谦[2] 张维[2] 王林[1] 周建平[1] 

机构地区：[1]陕西省人民医院核医学科,西安710068 [2]陕西省人民医院神经内科,西安710068

出　　处：《诊断学理论与实践》2005年第2期110-112,共3页Journal of Diagnostics Concepts & Practice

摘　　要：目的:研究癫痫发作期与发作间期同侧对照99mTc-ECD局部脑血流(rCBF)单光子发射计算机体层摄影术(SPECT)显像对癫痫灶的定位诊断价值。方法:对54例癫痫患者行发作间期显像,其中10例行发作期显像,并与皮层脑电图(EEG)、计算机断层扫描或磁共振显像(CT/M RI)、深部皮层脑电图(EcoG)结果进行对比分析。结果:癫痫发作期与发作间期rCBF SPECT显像对癫痫灶具有较高的检出率和定位率,优于EEG、CT/M RI,低于EcoG,但rCBF在发作期与发作间期的比较差异无显著性(P>0.05)。结论:发作间期rCBF SPECT显像可以成为癫痫灶方便而有效的定位方法,若加上发作期rCBF显像则定位更佳。Objective To evaluate the value of 99mTc-ECD brain SPECT imaging for localization of epileptic foci in patients at ictal and interictal period. Methods Brain SPECT imaging in the interictal period was performed in 54 epileptic patients and ten of them received brain SPECT imaging in the ictal period. The results were compared with that of CT/MRI, EEG and EcoG. Results Brain SPECT imaging in the ictal and interictal period showed high positive rate and foci localization rate, which was superior to EEG and CT/MRI. There was no significant difference (P>0.05) between the results obtained by brain SPECT imaging in the ictal period and those in the interictal period. Conclusions Brain SPECT imaging in the interictal period might be a simple and valuable method for the localization of the epileptic foci. The localization will be more accurate when brain SPECT imaging in the interictal period is combined with that in the ictal period.

关 键 词：SPECT显像 局部脑血流 单光子发射计算机体层摄影术 诊断比较 ^99MTC-ECD 脑电图(EEG) 计算机断层扫描 发作间期 癫痫发作期 影像 定位诊断价值 CT/MRI RCBF显像 磁共振显像 皮层脑电图 癫痫患者 对比分析 EcoG 定位方法 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R743.33[医药卫生—临床医学]