对间日疟病程初期原虫密度的观察  

OBSERVATION ON PARASITE DENSITY IN THE EARLY STAGE OF VIVAX MALARIA

作　　者：李华宪[1,2] 杨柏林[1,2] 胡惠仙 汪文仁[1,2] 王文俊[1,2] 李兴亮[1,2] 王翔[1,2] 李崇珍[1,2] 黄国珍[1,2] 

机构地区：[1]云南省疟疾防治研究所 [2]中国预防医学科学院寄生虫病研究所

出　　处：《中国寄生虫学与寄生虫病杂志》1994年第2期119-121,共3页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：滇南的实验结果显示，人工接种当地间日疟原虫子孢子后，经短潜伏期发病的３８名志愿者，首次见虫时间为８－１３ｄ，首次见虫和临床初发时的原虫密度分别为０．２－１．６和０．６－４０４０个／μｌ。造成如此明显差异的原因，似与虫现期和临床初发间的时间距离密切有关，表现为感染后临床初发的时间越早，多数病例于首次见虫时的原虫密度越低，反之则高。文中讨论了这一问题在病原生物学和流行病学上的重要性。Thirty eight cases were artificially infected with local Plasmodium vivax sporozoites and experienced onsets of acute attacks after a short incubation period.The parasite densities upon the patent of malaria parasites in the peripheral blood and the primary clinical onset were 0.2-1.6 and 0.6-4 040/μl,respectively.Such significant difference in parasitaemia level seems to be closely related to the interval between the initial parasitaemia and the first onset,as indicated by the fact that for the majority of cases,the earlier the appearance of clinical attack after sporozoite inoculation,the lower the parasite density at the beginning of the patent period,while primary onsets of later occurrence,in those with higher initial parasitemia.The biological and epidemiological significance of the evidence was discussed.

关 键 词：间日疟原虫 疟原虫 潜伏期 

分 类 号：R382.31[医药卫生—医学寄生虫学]