已治愈血吸虫病患者肝脏的超声影像与血清氨基酸的观察  

HEPATIC ULTRASONOGRAPHIC IMAGING AND SERUM AMINO ACID LEVELS IN CURED SCHISTOSOMIASIS CASES

作　　者：林新霖[1,2] 陈桂光[1,2] 李金炎[1,2] 

机构地区：[1]福建医学院附一医院 [2]福建医学院

出　　处：《中国寄生虫学与寄生虫病杂志》1994年第2期143-146,共4页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：１５例日本血吸虫病治愈后５－１５年以上无其他肝病者的肝脏Ｂ超检查仍显示程度不等的典型血吸虫病性肝纤维化影像，可分为Ⅰ斑点型、Ⅱ龟甲型和Ⅲ网斑型。Ⅱ、Ⅲ型同时存在肝门静脉与脾静脉的内径增宽。血清中游离氨基酸测定发现１８种常见氨基酸中８种含量显著降低，其中３种（苏、缬、色）为人体必需氨基酸。３例Ⅲ型患者的芳香族与支链族的氨基酸比值有所升高，呈现高氨基酸血症，提示肝脏严重损害导致肝功能减退和氨基酸代谢异常。Ultrasonography(B mode)of liver and serum amino acid levels were studied in 15 cases of schistosomiasis japonica who had been cured for more than 5-15 years.Typical B ultraso nic images of hepatic fibrosis due to schistosomiasis were found in all patients which could be classified into three types,namely,the spotty type(Ⅰ),the tortoise shell type(Ⅱ) and the net patchy type(Ⅲ)according to the patterns of echogenic bands.Moderate to marked echogenic thickening of portal vein wall,and dilation of portal and splenic veins were revealed in patients with type Ⅱ and Ⅲ images. Free amino acids in sera were determined by using HPLC AAAS.The result revealed that the concentration of 8 nonessential and 3 essential amino acids(threonine,valine,tryptophan)were significantly decreased in the 15 patients.The ratio of aromatic to aliphatic amino acid was markedly elevated in 3 patients of type Ⅲ.The serum amino acid imbalance was at tributed to the severe hepatic damage and impaired liver function.

关 键 词：血吸虫病 超声波诊断 氨基酸 

分 类 号：R532.21[医药卫生—内科学]