白细胞介素6基因174G/C多态性与胰岛素抵抗的关系  

The Relationship of Interleukin-6 Gene 174G/C Polymorphism and Insulin Resistance

作　　者：杨冀衡[1] 罗国辉[1] 陆泽元[2] 胡雪松[1] 新霞[1] 张东辉[1] 许香广[1] 

机构地区：[1]广东医学院附属福田人民医院心内科,广东省深圳市518033 [2]广东医学院附属福田人民医院内分泌科,广东省深圳市518033

出　　处：《中国动脉硬化杂志》2005年第1期101-104,共4页Chinese Journal of Arteriosclerosis

基　　金：深圳市科技局基金 ( 2 0 0 2 0 413 6)资助

摘　　要：目的　了解中国南方汉族人白细胞介素 6基因 174G/C多态性与胰岛素抵抗的关系。方法　应用聚合酶链反应一限制片长多态性分析方法测定了 6 9例胰岛素抵抗指数高值者和 6 9例胰岛素抵抗指数低值者的白细胞介素 6基因 174G/C多态性 ,并结合血压、血糖、血脂等相关指标进行横断面分析。结果　中国南方汉族人白细胞介素 6基因 174G/C多态性以GG纯合子基因型为主 ,分布频率为 136 / 138(98.5 5 % ) ,GC杂合子基因型分布频率为 2 / 138(1.4 5 % ) ,CC突变基因型未发现 ,各基因型与胰岛素抵抗指数无相关性。结论　中国南方汉族人白细胞介素 6基因Aim To understand the relationship of interleukin-6-gene 174G/C polymorphism and insulin resistance in Han people in south China. Methods Interleukin-6-gene 174G/C polymorphism were detected in 69 patients with high insulin resistance index and 69 control with low insulin resistance index by polymerase chain reaction-restriction fragment length polymorphism analytical method, meanwhile, combined with blood pressure, plasma glucose, blood fat, et al to undertake cross-sectional study. Results In Han people in south China, interleukin-6-gene 174G/C polymorphism main was G/G homogenotype and distribution frequency was 136/138 (98.55%), G/C hetrogenotype distribution frequency was 2/138(1.45%), C/C mutant genotype had not been found. There was no relationship between the kinds of genotype and insulin resistance index. Conclusion Maybe there is no relationship between interleukin-6-gene 174G/C polymorphism and insulin resistance in Han people in south China.

关 键 词：内科学 胰岛素抵抗 聚合酶链反应一限制片长多态性 白细胞介素6 基因多态性 白细胞介素6-174G/C 基因型 等位基因 

分 类 号：R5[医药卫生—内科学]