(+)-MethylCembra-1,3,7,11-tetraene-16-carboxynate的不对称合成研究  

Asymmetric Synthesis of Natural Macrocyclic Diterpene(+)- Methyl Cembra-1,3,7,11-tetraene-16-carboxynate

作　　者：孙彬[1] 梅天胜[1] 刘佐胜[1] 李裕林[1] 李瀛[1] 彭立增 

机构地区：[1]兰州大学功能有机化学国家重点实验室,兰州730000 [2]山东鲁南制药股份有限公司,临沂276003

出　　处：《高等学校化学学报》2005年第5期880-882,F011,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20072012);高校博士学科点基金资助.

摘　　要：The first asymmetric synthesis of (+)-methyl cembra-1,3,7,11-tetraene-16-carboxynate, a naturally occurring cembrane-type macrocyclic diterpene isolated from Sinularia mayi, was achieved via general approach by employing an intramolecular McMurry coupling and Sharpless asymmetric epoxidation as the key steps from readily available starting materials. The synthesis presented here verifies that the absolute configuration of compound 1 was assumed as 15R.The first asymmetric synthesis of (+)-methyl cembra-1,3,7,11-tetraene-16-carboxynate, a naturally occurring cembrane-type macrocyclic diterpene isolated from Sinularia mayi, was achieved via general approach by employing an intramolecular McMurry coupling and Sharpless asymmetric epoxidation as the key steps from readily available starting materials. The synthesis presented here verifies that the absolute configuration of compound 1 was assumed as 15R.

关 键 词：西松烷型大环二萜 天然产物 不对称合成 

分 类 号：O621.34[理学—有机化学]