地奥心血康中的两个新甾体皂苷  

Two New Steroidal Saponins from Di’aoxinxuekang

作　　者：陈洪超[1] 付铁军[1] 刘忠荣[1] 廖循[1] 丁立生[1] 

机构地区：[1]中国科学院成都生物研究所国家天然药物工程技术研究中心,成都610041

出　　处：《化学学报》2005年第9期869-872,i004,共5页Acta Chimica Sinica

摘　　要：通过正相和反相硅胶柱层析,从地奥心血康药粉的正丁醇萃取物中分离纯化出2个微量的新甾体皂苷,通过MS和NMR(包括HMQC,HMBC和NOESY)等波谱解析,结合化学降解分析将其结构鉴定为3β,26-二醇-25(R)-?5,20(22)-二烯-呋甾-26-O-β-D-吡喃葡萄糖苷(1)和26-O-β-D-吡喃葡萄糖基-3β,20α,26-三醇-25(R)-?5,22-二烯-呋甾-3-O-α-L-吡喃鼠李糖基(1→2)-[α-L-吡喃鼠李糖基(1→4)]-β-D-吡喃葡萄糖苷(2).Two new furostanol-type steroidal saponins were isolated from Di'aoxinxuekang, the total saponin from the roots of Dioscorea panthaica and D. nipponica. On the basis of spectroscopic and chemical evidence, their structures were elucidated as 3 beta,26-diol-25(R)Delta(5,20(22))-dienofurostan-26-O-beta-D-glucopyranoside (1) and 26-O-beta-D-glucopyranosyl-3,beta,20 alpha,26-triol-25(R)-Delta(5,22) -dienofurostan-3-O-alpha-L-rhamnopyranosyl(1 -> 2)-[alpha-L-rhamnopyranosyl(1 -> 4)]-beta-D-glucopyranoside (2).

关 键 词：皂苷 甾体 吡喃葡萄糖苷 硅胶柱层析 分离纯化 HMQC 波谱解析 HMBC 结构鉴定 化学降解 葡萄糖基 萃取物 正丁醇 NMR 二烯 反相 二醇 

分 类 号：TQ461[化学工程—制药化工]