核转录因子-κBP^(50)蛋白及其抑制蛋白IκBα表达与食管鳞癌浸润转移的关系  

Relationship between the expression of NF-κB P^(50) and its suppressor protein IκNα and infiltration and metastasis of esophageal squamous cell carcinoma

作　　者：李道明[1] 李珊珊[1] 赵志华[1] 任秀华[2] 高冬玲[1] 曹静[1] 李海梅[1] 闫爱华[2] 

机构地区：[1]郑州大学第一附属医院河南省肿瘤病理重点实验室,河南郑州450052 [2]郑州大学基础医学院

出　　处：《山东医药》2005年第11期13-15,共3页Shandong Medical Journal

基　　金：河南省自然科学基金资助项目(No.0411043200)

摘　　要：目的探讨核转录因子κB(NF-κB)P50蛋白及其抑制蛋白IκBα表达与食管鳞癌浸润转移的关系。方法用免疫组化SP法检测61例食管鳞癌患者癌组织中NF-κBP50、IκBα蛋白的表达情况。结果NF-κBP50、IκBα蛋白的胞浆表达与食管鳞癌的组织学分级、浸润深度和淋巴结转移无关,但其胞核表达与食管鳞癌的淋巴结转移有关(P均<0.05);癌组织中IκBα蛋白的胞浆和胞核阳性率均高于NF-κBP50蛋白(P均<0.01),但无相关关系。结论NF-κBP50、IκBα蛋白的胞核表达与食管鳞癌的淋巴结转移有关。Objective To study the relationship between the expression of P50 proteins of nuclear transcription factor kappa B(NF-κB),its suppressor protein IκBα and the infiltration, metastasis of esophageal squamous cell carcinoma. Methods SP immunohistochemical method was performed to detect the expressions of P50 proteins of NF-κB and protein IκBα in 61 cases of esophageal squamous cell carcinoma specimens. Results There was no relationship between the positive expression of P50,protein IκBα in plasma and the tumour grade, depth of infiltration and lymphatic metastasis of esophageal squamous cell carcinoma,but the positive rate of P50, protein IκBα expression in nuclei and the lymphatic metastasis of esophageal squamous cell carcinoma were correlative(P<0. 05). In the esophageal squamous cell carcinoma,the positive rates of protein IκBα in plasma and nuclei are both higher than that of P50 protein, the difference is significant (P<0.01), but there was no correlationship between them. Conclusions The expression of P50 proteins of NF-κB and suppressor protein-IκBα in nuclei may be correlated with the lymphatic metastasis in esophageal squamous cell carcinoma.

关 键 词：IKBΑ 癌浸润转移 核转录因子 抑制蛋白 白及 淋巴结转移 免疫组化SP法 食管鳞癌 组织学分级 表达情况 浸润深度 相关关系 癌组织 核表达 癌患者 a蛋白 阳性率 NF 胞浆 

分 类 号：R651.2[医药卫生—外科学] R730.21[医药卫生—临床医学]