丙氧氨酚片对急性疼痛的Ⅱ期临床试验  

PHASE Ⅱ CLINICAL TRIAL OF PROPOXYPHENE NAPSYLATE -ACETAMINOPHEN TABLTE IN THE PATIENTS WITH ACUTE PAIN

作　　者：程源深[1] 阮邹荣[1] 潘以正[1] 郭琦[2] 胡伟恩[3] 蒋定国[4] 祝浩强[5] 

机构地区：[1]浙江医科大学附属二院临床药理所,杭州310009 [2]浙江医科大学附属一院,杭州310009 [3]杭州市第一人民医院,杭州310001 [4]江苏省人民医院,南京210029 [5]江苏省肿瘤医院,南京210008

出　　处：《中国临床药理学杂志》1994年第3期148-152,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：对424例急性疼痛病人,采用随机对照双盲法,观察单次给予丙氧氨酚片或安慰剂或氨酚待因片.三组病例统计结果表明,丙氧氨酚片的有效的镇痛效应率为 96.03%,安慰剂组为41.51%,氨酚待因组为81.16%.上述结果说明丙氧氨酚片在解除急性疼痛方面有较好的疗效.424 volunteers with acute pain were selected and randomized into 3 drug groups. Eachof them received single dose of tablets of placebo, propoxyphene napsylate-acetaminophen or acetaminophen and codeine respectivily by means of double-blind method. On the basis of similar background in the three groups, we founded that the validity rate of the tested new drug, comparison groups and placebo groups were 96. 03%, 81. 16% and 41. 57% respectivily. The data mentioned above showed that propoxyphene napsylate-acetaminophen possessed good effect on relieving pain.

关 键 词：丙氧氨酚片 Ⅱ期临床试验 急性疼痛 

分 类 号：R971.1[医药卫生—药品] R441.105[医药卫生—药学]