对甲氧基肉桂酸乙酯的合成研究  

Synthesis of ethyl p-methoxy cinnamate

作　　者：张红[1] 丁盈红[1] 李若琦[1] 

机构地区：[1]广东药学院有机化学教研室,广东广州510240

出　　处：《广东药学院学报》2005年第2期117-119,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的与方法　以对甲氧基苯甲醛为原料,醋酸铵为催化剂,经Knoevenagel反应,采用微波辐射技术合成了中间体对甲氧基肉桂酸,再以对甲苯磺酸为催化剂,经酯化反应得对甲氧基肉桂酸乙酯。结果与结论两步反应的产率分别为87. 8%和91. 0%,产品结构经IR和1H NMR(CDCl)确证。An efficient synthesis of p-methoxy cinnamic acid, a key intermediate for ethyl p-methoxy cinnamate, was developed on the basis of Knoevenagel condensation of p-anisaldehyde with a catalytic amount of ammonium acetate under microwave irradiation in the yield of 87.8%. Then, p-methoxy cinnamic acid obtained was converted to ethyl p-methoxy cinnamate by esterification using p-toluenesulfonic acid as catalyst in excellent yield (91.0%). The structures of p-methoxy cinnamic acid and ethyl p-methoxy cinnamate were confirmed by IR and ~1H-NMR.

关 键 词：对甲氧基肉桂酸 对甲氧基肉桂酸乙酯 KNOEVENAGEL缩合 微波辐射 酯化 

分 类 号：R914.5[医药卫生—药物化学]