层粘连蛋白受体单克隆抗体对人肺癌细胞形态、粘着及铺展的影响  

EFFECTS OF MONOCLONAL ANTIBODIES TO LAMININ RECEP-TORS ON THE MORPHOLOGY ADHESION AND SPREADING OFHUMAN LUNG CARCINOMA CELL

作　　者：吴珊[1] 王勇[1] 李玉林[1] 郑杰[1] 吴秉铨[1] 

机构地区：[1]白求恩医科大学基础医学院病理,北京医科大学基础医学院病理,白求恩医科大学一院心外科

出　　处：《中国免疫学杂志》1994年第5期294-296,共3页Chinese Journal of Immunology

摘　　要：应用体外细胞培养，观察了层粘连蛋白受体单克隆抗体（ＭｃＢ＿１）加入培养液或预处理人肺巨细胞癌（ＰＧ）和肺腺癌（ＰＡａ）后某些生物学行为的改变。在体外ＭｃＢ＿１预孵育可抑制ＰＧ和ＰＡａ在层粘连蛋白基质上的粘着和铺展。培养液中加入ＭｃＢ＿１经扫描电镜观察，ＭｃＢ＿１明显改变该两种细胞的表面形态。说明层粘连蛋白受体在肿瘤浸润和转移中可能起重要作用。层粘连蛋白受体单克隆抗体在阻断肿瘤转移的发生上可能具有应用价值。he effects of laminin recepter monoclonal antibodies(McB_1)on the biological behaviors ofhuman giant cell carcinoma(PG)as well as adenocarcinoma(PAa) of Iung were investigated byusing cell culture. The results showed that McB_1 could inhibit adhesion and spreading of PG andPAa cells on the Iaminin substrate. The monoclonal antibodies were able to induce alteration ofthe cellular morphology. It is suggest that laminin receptor may play an important role in theprocess of tumor invasion and metastasis and the related monoclonal antibodies may contribute tothe therapy of tumor metastasis.

关 键 词：单克隆抗体 层粘连蛋白 受体 肺癌 

分 类 号：R734.203[医药卫生—肿瘤]