多奈哌齐与安慰剂治疗脑外伤后记忆障碍的对照研究  

A comparative study of aricept and placebo in the treatment of memory disorder after traumatic brain injury

作　　者：孙呈勇[1] 唐济生[2] 徐严明[3] 张洪新[1] 巩秀芹[1] 王抚临[1] 崔吉俊[1] 

机构地区：[1]胜利石油管理局胜利医院,257055 [2]山东省精神卫生中心 [3]四川大学华西医院

出　　处：《山东精神医学》2005年第2期69-71,共3页Shangdong Archives of Psychiatry

摘　　要：目的探讨多奈哌齐治疗脑外伤后记忆障碍的有效性和安全性.方法对59例脑外伤病人随机分成两组,分别给予口服多奈哌齐与安慰剂治疗6个月,采用WMS评价临床疗效,定期查体和实验室检查评价药物不良反应.结果治疗后多奈哌齐组WMS各项评分均有显著提高(P＜0.01～0.05),与安慰剂比较,WMS评分长时记忆、瞬时记忆、记忆商有统计学差异(P＜0.05).口服多奈哌齐未见严重药物不良反应.结论多奈哌齐治疗脑外伤后记忆障碍有效,安全性好.Objective To explore the efficacy and the safety of aricept in the treatment of memory disorder after brain injury.Methods A total of 59 patients with traumatic brain injury were divided into two groups receiving aricept or placebo respectively for 6 months. Wechsler memory scale(WMS) was used to evaluate the efficacy ,and side effects were assessed at the same time. Results There were significant improvement in every factor score of WMS after treatment in aricept group( P <0.01~0.05), and the aricept group had significant greater improvement in long-term memory, immediate memory, memory quotient(MQ) than the placebo group( P <0.05). Severe side effects was not found in the patients with aricept. Conclusion Aricept is effective in treating memorydisorder after traumatic brain injury with well tolerance and safety.

关 键 词：多奈哌齐 安慰剂治疗 记忆障碍 脑外伤后 对照研究 严重药物不良反应 统计学差异 WMS 外伤病人 临床疗效 检查评价 长时记忆 瞬时记忆 安全性 实验室 治疗后 记忆商 口服 评分 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R473.73[医药卫生—临床医学]