γ-干扰素和腺苷脱氨酶测定对结核与癌性胸腔积液诊断价值的对比研究  

Comparison of the diagnostic value of IFN-γ with ADA in tuberculosis and malignant pleural effusions

作　　者：张秀琴[1] 韩亚群[1] 丁小旭[1] 

机构地区：[1]河北省承德医学院附属医院检验科,承德067000

出　　处：《陕西医学杂志》2005年第5期606-608,共3页Shaanxi Medical Journal

摘　　要：目的研究胸腔积液γ-干扰素(IFN-γ)水平对结核性与癌性胸腔积液鉴别诊断的价值。方法用酶联免疫吸附分析法(ELISA)和氨试剂法检测80例胸腔积液(40例结核性积液和40例癌性积液)中IFN-γ水平和腺苷脱氨酶活性,并将IFN-γ检测结果与ADA测定结果进行对比。结果IFN-γ对结核性积液诊断的敏感度为90%,特异度为100%,正确率为95%;ADA对结核性胸腔积液诊断的敏感度为80.0%,特异度为100%,正确率为90%。结论胸腔积液IFN-γ水平的检测对鉴别结核性与癌性胸腔积液明显优于ADA,可作为一种诊断结核性胸腔积液的有力手段。Objective: To study the value of interferon gamma (IFN-γ) in differentiating tuberculosis from malignant pleural effusions. Methods: Both IFN-γ and ADA of 80 specimens of pleural effusions (40 cases of tuberculosis pleural effusions and 40 cases of malignant pleural effusions) were analyzed by enzyme linked immunosorbet assay ( ELISA) and ammoniacal reagent method . Results: The sensitive rate and special rate of IFN-γ to diagnose tuberculosis pleural effusions were 90% and 100%,and that of ADA were 80% and 100%, the accuracy of IFN-γ and ADA were 95% and 90%. Conclusion: The results indicate that the detection of IFN-γ in pleural effusions is more sensitive, more accurate than ADA in differentiating tuberculosis from malignant pleural effusions and can be used as adjunctive measure in the diagnosis of tuberculosis pleural effusions.

关 键 词：癌性胸腔积液 Γ-干扰素 腺苷脱氨 对比研究 诊断价值 结核性胸腔积液 酶测定 酶联免疫吸附分析法 结核性积液 IFN-γ ADA 鉴别诊断 癌性积液 测定结果 检测结果 敏感度 特异度 正确率 水平 酶活性 

分 类 号：R730.53[医药卫生—肿瘤] R512.62[医药卫生—临床医学]