唾液地塞米松抑制试验与精神分裂症患者阴性、阳性症状  

Salivary dexamethasone suppression test and positive and negative symptoms in schizophrenia

作　　者：赵汉清 端义杨 刘维莉 薛蕴庄 张理义 苏宗荣 高柏良 

机构地区：[1]常州解放军第一0二医院

出　　处：《中国神经精神疾病杂志》1994年第4期216-218,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：以３０例精神分裂症患者作唾液地塞米松抑制试验（ＳＤＳＴ）。结果显示ＳＤＳＴ与血浆地塞米松抑制试验（ＰＤＳＴ）结果相同。唾液皮质醇浓度与血浆浓度高度相关。３０例中有１２例ＳＤＳＴ至脱抑制。发现脱抑制现象与疾病的严重程度和阳性症状有关，提示精神分裂症患者在病情严重并伴明显的阳性症状时有下丘脑—垂体—肾上腺轴的异常。Study of salivary dexamethasone suppression test (SDST) was conducted in 30 female schizoph renic pateints with positive and negative symptoms.8 cases of them, received plasma dexamethasone suppression test simultaneously. High correlationship was found between the two methods. The results showed: (1) Plasma cortisol level related to salivary cortisol level closely (r=0.79 P<0.05). (2) 12 cases (12/30, 40%) presented non-suppression response,related to positive sylnptoms and morbid severity significantly. The authors strongly suggest that the patient may have hypothalamus-pituitary adrenal axis (HPA) dysfunction if he is prone to severe morbidity with positive symptoms.

关 键 词：精神分裂症 唾液 地塞米松 

分 类 号：R749.305[医药卫生—神经病学与精神病学]