新型镇痛药ω-芋螺毒素的合成等效物ziconotide  

Ziconotide,a novel antinociceptive agent

作　　者：陈时宏 

机构地区：[1]厦门北大之路生物工程有限公司厦门生物工程技术研究中心,厦门361009

出　　处：《中国新药杂志》2005年第4期490-495,共6页Chinese Journal of New Drugs

摘　　要：ω-芋螺毒素的合成等效物Ziconotide作为一种新型非吗啡类镇痛剂,是首个应用于临床的具有神经元特异性的N-型电压敏感型性钙通道阻滞剂。大量临床前和临床资料证明,通过鞘内注射Ziconotide治疗严重慢性疼痛,可缓解其他治疗手段包括鞘内注射吗啡无效的疼痛;且长时间使用该药物不会产生耐受性和成瘾性。Ziconotide is a novel non-opioid analgesics, developed for the treatment of severe chronic pain. Ziconotide is the synthetic equivalent of the cone snail peptide ω-conotoxin MV II A, the first of a neurone-specific N-type voltage-sensitive calcium channel blocker. Clinical studies demonstrated that intratheral ziconotide may be effective in patients with pain that is refractory to opioid therapy or those with intolerable opioid-related adverse effects. There was no evidence of tolerance to ziconotide or of addictive behavior in animals and human.

关 键 词：ZICONOTIDE 鞘内注射 N-型电压敏感性钙通道阻滞剂 镇痛作用 

分 类 号：R971.2[医药卫生—药品] R914.5[医药卫生—药学]