强烈化疗与急性白血病患儿正常甲状腺功能病态综合征  

Euthyroid sick syndrome of children acute leukemia with strong chemotherapy

作　　者：王菊香[1] 钱江潮[1] 周海霞[1] 李原[1] 阮积晨[1] 章佳珠[1] 

机构地区：[1]温州医学院附属育英儿童医院血液科,325027

出　　处：《中国小儿血液》2005年第2期57-58,53,共3页China Child Blood

摘　　要：目的　探讨强烈化疗对急性白血病患儿甲状腺激素(TH)水平的影响。方法　用放射免疫分析法分别测定3 0例急性白血病(AL)患儿强烈化疗前、后血清甲状腺激素(TH)的水平,并以2 8例健康儿童为对照。结果　完全缓解(CR)后的AL患儿,强烈化疗后总甲状腺素(TT4 )和总三碘甲腺原氨酸(TT3)明显低于强烈化疗前及健康对照组(P <0.0 0 1 ) ,而促甲状腺激素(TSH)强烈化疗前后无显著差异(P >0.0 5 )。结论　强烈化疗可引起AL患儿TH水平的变化,且此变化可反映强烈化疗后患儿的全身状况。Objective To explore the effects strong chemotherapy on thyroid hormones of children acute leukemia(AL). Methods To measure the level of thyroid hormones in serum of 30 children acute leukemia before and after strong chemotherapy by using radiommunoassay. The control group consisted of 28 children of health. Results After strong chemotherapy, total T_3(TT_3) and total T_4 (TT_4) were lower than before and control group (P<0.001). The change have not taken place in thyroid-stimulating hormone (TSH) (P>0.05). Conclusion Thyroid hormones' change take place after strong chemotherapy. When having conditions, the monitor should been done.

关 键 词：正常甲状腺功能病态综合征 白血病患儿 强烈化疗 促甲状腺激素(TSH) 总三碘甲腺原氨酸 放射免疫分析法 血清甲状腺激素 急性白血病 健康对照组 总甲状腺素 健康儿童 完全缓解 化疗前后 化疗后 水平 AL 

分 类 号：R733.71[医药卫生—肿瘤]