大鼠实验性重症肌无力的免疫电镜研究  

An immunoelectron microscopic study on experimental myasthenia gravis of rat

作　　者：宋东林[1] 刘翠兰[1] 陈晋文[1] 吕强[1] 石进[1] 安春华 

机构地区：[1]空军总医院神经内科

出　　处：《中国神经精神疾病杂志》1994年第2期80-82,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：本文成功地制作了大鼠ＥＡＭＧ模型，在观察动物临床表现和检测血清ａｎｔｉ－ＡｃｈＲＡｂ的同时还对ＮＭＪ进行了电镜观察。ＥＡＭＧ急性期大鼠ＮＭＪ出现巨大吞噬细胞浸润，而突触前，后膜改变不明显；在慢性期ＮＭＪ与肌纤维间隙不规则，突触前、后膜间隙扩大，突触后膜上的ＡｃｈＲ明显减少，触脚亦减少，突触后膜变得简单化，而神经终未端内的囊泡和线粒体却基本保持完好。A model of experimental myasthenia gravis (EAMG) on rats was made sucessfully. We studed neuromuscular junction (NMJ) under the electron microscopy, while observing their clinical manifestation and assaying their anti-AchR level in the serum. At the early stage of EAMG, the macrophagn occured around the NMJ. But no dramatic changes could be found on the postsynaptic membrane and presynaptic membrane. At the chronic stage, the NMJ and the gaps among muscular fibers became irregular. The synaptic clefts were enlarged. the number of AchR on the postsynaptic membrane reduced obviously, and the number of antennae also reduced, so postsynaptic membrane became simplified. But the folliculi and mitochondria in the nerve terminals remained intact.

关 键 词：重症肌无力 自身免疫 

分 类 号：R746.103[医药卫生—神经病学与精神病学]