奎硫平、利培酮对首发精神分裂症患者认知功能及P300的影响  

Cognitive Function and P300 Potentials in First-Episode Schizophrenia Treated with Quetiapine and Risperidone

作　　者：王长虹[1] 李晏[1] 刘旭[2] 王来海[2] 潘苗[2] 穆俊林[2] 

机构地区：[1]中南大学湘雅二院精研所,长沙410011 [2]新乡医学院第二附属医院,新乡453002

出　　处：《中国心理卫生杂志》2005年第5期333-336,共4页Chinese Mental Health Journal

基　　金：河南省自然科学基金资助项目(994024500)

摘　　要：目的:比较利培酮和奎硫平对首发精神分裂症患者认知功能的影响。方法:采用随机对照研究连续观察12周,利培酮组32例,剂量范围为1～7mg/d,奎硫平组35例,剂量范围25～750mg/d。进行PANSS、韦氏记忆量表(WMS)和事件相关电位P_(300)检查。结果:首发精神分裂症患者的长时记忆、短时记忆、瞬时记忆及记忆商数(MQ)受损较为明显,与对照组比较差异有显著性(P<0.05)。P_(300)电位成分中P_2、N_2及P_3潜伏期明显延长,P_2及P_3波幅明显降低,与对照组比差异均有显著性(P<0.05)。经过12周治疗,奎硫平和利培酮组PANSS 总分、阳性症状分、阴性症状分及一般精神病理症状分均降低,两组相比差异无显著性(P>0.05),说明两药的疗效相当。服用奎硫平及利培酮治疗的患者WMS 的再认、联想、理解及记忆商(MQ)均明显高于治疗前,治疗后两组患者WMS 各项目之间比较差异均无显著性(P>0.05);两组在治疗前后P_(300)各指标之间差异无显著性。结论:首发精神分裂症患者存在着认知功能障碍,奎硫平与利培酮对改善首发精神分裂症认知功能的作用相当。Objective:To compare the effects of quetiapine and risperidone on cognitive function of first-episode schizophrenic patients.Methods:A randomized comparative clinical design was applied to compare the cognitive function of 67 patients with first-episode schizophrenia treated with quetiapine(n=35,25-750mg/d)and risperidone(n=32,1-7rag/d)before and after 12-week treatment.PANSS,WMS and P300 were used to evaluate adverse effects of drags and cognitive function.Results:The Long-term memory,Short-term memory,Immediate memory,Memory Quotient of first-episode schizophrenia were damaged obviously.Latency periods of P_2、N_2 and P_3 of P_(300) potentials with first-episode schizophrenia group were longer than the control group,The amplitudes of P_2 and P_3 of P_(300) potentials with first-episode schizophrenia group were lower than the control group(P<0.05).After 12-week treatment,some of the scores in two groups were decreased significantly,including total scores of PANSS,scores of positive symptom scores,negative symptom and general psychopathology subscales.The decreased rate had no significant differences between the two groups,which indicated a similar effectiveness in both groups.In both groups, the Recognize,Association,Comprehend,MQ of WMS were significantly higher after treatment,while no differences in WMS and P300 between risperidone and quetiapine groups after treatment.Conclusion:The presence of cognitive dysfunction in first-episode schizophrenia has been confirmed.The study suggests that both quetiapine and risperidone can improve cognitive function of first-episode schizophrenic patients

关 键 词：首发精神分裂症患者 奎硫平 利培酮 PANSS 随机对照研究 P300检查 事件相关电位 韦氏记忆量表 P300电位 认知功能障碍 剂量范围 显著性 P3潜伏期 连续观察 长时记忆 短时记忆 记忆商数 瞬时记忆 P3波幅 阳性症状 病理症状 

分 类 号：R971.4[医药卫生—药品] R749.3[医药卫生—药学]