支气管动脉灌注化疗结合手术治疗中央型肺癌  

Bronchial artery infusion chemotherapy plus surgery in central type of lung cancer

作　　者：李加[1] 李建新[1] 梁定岸[1] 项光泽[2] 车斯尧[3] 

机构地区：[1]广东医学院第二附属医院胸外科,广东湛江524003 [2]广东医学院第二附属医院介入科,广东湛江524003 [3]广东省高州市人民医院外科,广东高州525200

出　　处：《广东医学院学报》2005年第2期137-138,共2页Journal of Guangdong Medical College

摘　　要：目的:总结5 6例中央型肺癌支气管动脉灌注化疗结合手术治疗经验。方法:对5 6例中央型肺癌进行支气管动脉灌注ADM(阿霉素)、MMC(丝裂霉素)、CDDP(顺铂)或CBP(卡铂) 1个月,然后进行剖胸探查术,行肺叶切除或支气管肺叶袖状切除术切除癌肿及纵膈淋巴结。结果:介入治疗1个月后,胸部CT影像学上癌肿缩小4 0 %～5 0 %者2 8例(5 0 .0 % ) ,缩小2 0 %～39%者2 0例(35 .7% ) ,缩小<2 0 %者8例(14 .3% )。对5 2例(92 .9% )行肺叶切除或支气管肺叶袖状切除术切除癌肿及纵膈淋巴结。术后并发胸腔感染、切口感染、肺部感染各1例。术后2 a生存率为75 .0 %。结论:外科手术仍是治疗肺癌的首选方法。对中央型肺癌先行支气管动脉介入治疗,待肿瘤缩小后再进行手术,能提高手术的切除率,也能减少全肺切除,从而提高生活质量和生存率。Objective: To summarize the experience of bronchial artery infusion chemotherapy plus surgery in central type of lung cancer. Methods: Adriamycin, mitomycin and cisplatin or carboplatin were infused by bronchial artery in 56 patients with central type of lung cancer, and lobectomy or bronchial sleeve resection plus nodal removal of mediastinum was performed 1 month later. Results: CT findings 1 month after arterial infusion showed that the tumor mass shrank to 40%～50% in 28 (50.0%), 20%～30% in 20 (35.7%) and <20% in 8 cases (14.3%). Fifty-two cases (92.9%) underwent surgery. Of them, 3 patients had thoracic, wound and pulmonary infection, respectively; and 2-year survival rate was 75.0%. Conclusion: The operation is the first choice for lung cancer. Preoperative bronchial artery infusion chemotherapy can improve the surgical success and survival rate in central type of lung cancer.

关 键 词：化疗 外科手术 中央型肺癌 支气管动脉灌注 

分 类 号：R734.2[医药卫生—肿瘤]