1例进展期前列腺癌的循证治疗  

Evidence-Based Treatment of a Patient with Advanced Prostate Cancer

作　　者：王慧[1] 董碧蓉[1] 

机构地区：[1]四川大学华西医院老年科,成都610041

出　　处：《中国循证医学杂志》2005年第5期415-418,共4页Chinese Journal of Evidence-based Medicine

摘　　要：针对进展期前列腺癌的治疗问题,运用循证医学的方法全面检索相关的临床治疗证据并进行质量评价。结果显示,各种雄激素阻断方法疗效相似,但早期进行雄激素全阻断的疗效更好;对激素不敏感性前列腺癌,采用米托蒽醌、强的松、多西他赛及苏拉明等化疗药物有一定疗效;锶89内照射的镇痛效果较传统的外照射好,而双磷酸盐无效;抗雄激素撤退可使部分患者前列腺特异性抗原下降,但临床疗效有待进一步评价。Through searching and evaluating the evidence on advanced prostate cancer, we found that different types of androgen deprivation had similar effect, and immediate androgen deprivation had survival benefit. For the patient with hormone-refractory prostate cancer, therapies including mitoxantrone, prednisone, docetaxel and surmine were more effective. Strontium-89 provided more effective pain relief than external beam radiation. And bisphophonate had no effect. Antiandrogen withdrawal suggested prostate specific antigen would decline, but the clinical outcome wasn't reported.

关 键 词：循环治疗 进展期前列腺癌 激素不敏感性前列腺癌 

分 类 号：R737.25[医药卫生—肿瘤]