白僵菌代谢物对慢性应激抑郁大鼠的抗氧化作用  

Effect of BCEF0083 on antioxidation in experimental chronic unpredictable stress rats

作　　者：程燕[1] 明亮[1] 周兰兰[1] 章功良[1] 闵小芬[1] 

机构地区：[1]安徽医科大学药理教研室,合肥230032

出　　处：《中国行为医学科学》2005年第5期396-397,共2页Chinese Journal of Behavioral Medical Science

基　　金：安徽省科技厅自然科学基金资助课题(00144415)

摘　　要：目的研究一种白僵菌代谢物(BCEF0083)对慢性应激抑郁模型大鼠糖水消耗量的影响和抗氧化作用。方法建立慢性不可预见性应激大鼠抑郁模型,观察BCEF0083对慢性应激抑郁模型大鼠糖水消耗量的影响,同时取血,测定超氧化物歧化酶(SOD)、谷光甘肽过氧化物酶(GSH PX)活力及丙二醛(MDA)含量。结果BCEF0083 25, 50, 100mg·kg 1 3个剂量组和Moc20mg·kg 1可不同程度增加慢性应激大鼠糖水摄入量,提高血浆SOD、GSH Px活性(P<0. 05 ),降低血浆中MDA含量(P<0. 01 )。结论BCEF0083能够改善实验性慢性应激抑郁大鼠行为;其抗抑郁作用机制可能与清除体内过多自由基、抗脂质过氧化有关。ObjectiveTo study the effect of bioactive compounds from entomogenous fungi (BCEF0083) on behaviour and antioxidation in chronic unpredictable stress model of depression in rats. MethodsThe behaviour of rats was tested by consumption of 1% sucrose solution and UV spectrophotometer analysis technique was used to detect the activity of SOD、GSH-PX and content of MDA in the chronic unpredictable stress model of depression in rats.ResultsBCEF0083 25、50、100mg·kg -1 and Moc20mg·kg -1 increased consumption of 1% sucrose solution and raised the activity of SOD and GSH-Px(P<0.05) and decreased the content of MDA(P< 0.01 ) in blood plasm of chronic stressed rats.ConclusionBCEF0083 could ameliorate the behaviour of chronic unpredictable stressed rats.The inhibition of lipid peroxidation and the scavenging of free radical may account for the observed antidepressant effect.

关 键 词：慢性应激抑郁 抗氧化作用 代谢物 白僵菌 超氧化物歧化酶(SOD) BCEF0083 谷光甘肽过氧化物酶 丙二醛(MDA) GSH-Px活性 抑郁模型大鼠 抗脂质过氧化 应激大鼠 不可预见性 MDA含量 方法建立 不同程度 大鼠行为 作用机制 消耗量 

分 类 号：R749.4[医药卫生—神经病学与精神病学]