毛瑞香化学成分研究  

Studies on the chemical constituents in roots of Daphne odora var. atrocaulis

作　　者：张薇[1] 张卫东[1] 李廷钊[1] 张川 柳润辉[1] 周耘[1] 苏娟[1] 

机构地区：[1]第二军医大学药学院,上海200433

出　　处：《中国中药杂志》2005年第7期513-515,共3页China Journal of Chinese Materia Medica

基　　金：国家高技术研究发展计划(863计划)项目(2003AA2Z3507);上海市科技发展基金项目(02DZ19147;01DJ19010)

摘　　要：目的:研究毛瑞香的化学成分。方法:应用色谱技术进行分离和纯化,通过光谱方法鉴定其化学结构。结果:得到16个化合物,鉴定其中的9个,分别为β谷甾醇(Ⅰ),对羟基苯甲酸乙酯(Ⅱ),反式2-丙烯酸3(3,4-二羟基苯基)二十二烷酯(Ⅲ),5,4′二羟基-7-甲氧基黄酮(即芫花素)(Ⅳ),2,4-二羟基嘧啶(Ⅴ),瑞香素(Ⅵ),双白瑞香素(Ⅶ),5,7,4′-三羟基黄酮-3醇(Ⅷ),β-胡萝卜苷(Ⅸ)。结论:化合物Ⅱ,Ⅲ,Ⅳ,Ⅴ,Ⅵ,Ⅷ,Ⅸ为首次从该植物中分得。Objective: To study the chemical constituents from Daphne odora var. atrocaulis . Method: The chemical constituents were isolated and repeatedly purified by silica gel column chromatography and the structures were elucidated by the NMR spectra and physico-chemical properties. Result: Sixteen compounds were obtained and nine of them were identified as β-sitosterol, 4-hydroxy ethylbenzoate, (2 E ),-2-propenoic acid,3-(3,4-dihydroxyphenyl)-decosylester, genkwanin, 2,4-dihydroxypyrimidine, daphnetin, daphnoretin, 5,7,4′-trihydroxyflavone-3ol, daucosterol. Conclusion: Seven compounds were obtained from D. odora var. atrocaulis . for the first time.

关 键 词：化学成分研究 毛瑞香 对羟基苯甲酸乙酯 β-胡萝卜苷 分离和纯化 Β-谷甾醇 二十二烷酯 二羟基苯基 双白瑞香素 三羟基黄酮 色谱技术 化学结构 化合物Ⅱ 谱方法 丙烯酸 芫花素 甲氧基 鉴定 

分 类 号：R284.1[医药卫生—中药学]