正常人单通道多焦视诱发电位的特征研究  

Single channel multifocal VEP studies in normal Chinese

作　　者：李建军[1] 徐亮[1] 白凤阁[1] 张蓉秀[1] 吴旬生[1] 孙秀英[1] 

机构地区：[1]首都医科大学北京同仁眼科中心北京市眼科研究所,100730

出　　处：《中华眼科杂志》2005年第4期355-363,共9页Chinese Journal of Ophthalmology

摘　　要：目的探讨国人单通道多焦视诱发电位(mVEP)多个位点的波形特征及其变异性.方法采用EDI多焦电生理系统单通道记录和分析mVEP.刺激图案含60个扇面的圆形飞镖盘样图形,对比度为99%,刺激频率为75Hz,测试野范围26°.m-系列长度为214.每眼记录分8段.双极电极跨立于枕骨粗隆上、下各3cm处.放大器增益105倍,通频带3～100Hz.应用Matlab程序对mVEP60个位点二阶一次反应测量与计算在40～130ms观察窗范围内主波峰-谷振幅与潜伏期.正常受试者64例,男性25例,女性39例,年龄13～66岁.对7例受试者在非同一日进行了2～7次的可重复性试验.用Excel与SPSS软件进行统计学分析.结果mVEP曲线阵列中,上、下半野波形通常极性相反,但在近垂直中线区及下方近水平线区,波形极性变异较大.左眼60个位点中各位点的平均振幅从0.177～0.401μV不等,振幅变异系数36.6%～60.7%;平均潜伏期从100～116ms,潜伏期变异系数8.8%～18.1%.较大振幅的波形呈'领结'状分布,在上方的周边区、沿垂直中线处及沿水平线下方mVEP反应振幅明显较低.上半野mVEP振幅较低区,其振幅变异一般也较小;下半野振幅较大的区域其振幅的变异也较大.所有60个位点的平均振幅男性均低于女性,其中30个位点差异有统计学意义(P<0.05).而性别对mVEP潜伏期影响很小,仅1/6的位点平均潜伏期差别有统计学意义(P<0.05).有1/3的位点(主要分布在垂直中线附近,尤其是下半野周边区垂直中线附近)年龄与振幅呈显著性正相关.年龄对潜伏期无显著影响.结论单通道mVEP在同一个体的不同位点以及不同个体间的同一位点主波峰-谷振幅变异均较大,在进行mVEP振幅异常分析时,需要考虑位点部位、性别与年龄等因素的影响.潜伏期变异小,且受性别、年龄的影响小,有可能成为临床检测的一个有用指标.(中华眼科杂志,2005,41:355-363)Objective To investigate the waveform characters of single channel mVEP and its variability in normal Chinese people. Methods VERIS Science 4.3 system was used to record and analyze single channel mVEP. The stimulation was performed with a 60 pattern segment dartboard configuration. The Michelson contrast was 99% and the repetition rate 75 Hz. Recording electrodes were placed 3 cm above and 3 cm below the inion. The m-14 sequence required 4 minutes of recording time per eye, which was divided into 8 short segments. The signal was amplified 100 000 times and band-pass filtered between 3 and 100 Hz. The first slices of second kernel at 60 locations were analyzed. The main wave peak-to-trough amplitude and latency from 30 to 130 ms signal window were measured and calculated with the costumed Matlab program. The study included 64 normal subjects (39 women and 25 men). The age range was 13-66 years. 7 subjects were tested 2-7 times on different occasions for reproducibility. The statistic analysis was performed with Excel and SPSS. Results In mVEP trace array, the polarity of upper hemifield traces was usually opposite to lower hemifield traces. However, at near vertical meridian areas and near below horizontal meridian areas, the trace polarity had some variability. The main wave mean amplitudes of 60 location responses in left eye were from 0.177 μV to 0.401 μV. The amplitude CVs for 60 locations were from 36.6% to 60.7%. The mean latencies of 60 location responses were from 100 to 116 ms, and latency CVs were from 8.8% to 18.1%. The smaller signals located in zones of upper periphery, along vertical meridian, below horizontal meridian and the larger signals located in near horizontal meridian areas and near non-axial meridian areas which distribution is like a bow tie. There was smaller amplitude variability in the some upper hemifiled locations with smaller amplitude, and there was larger amplitude variability in the some lower hemifiled locations with larger amplitude. The mean amplitudes of all 60 locat

关 键 词：单通道多焦视 诱发电位 mVEP 波形特征 潜伏期 

分 类 号：R770.4[医药卫生—眼科]