^(18)F-FDG-SPECT/CT显像在肺癌诊断中的临床价值  

Clinical evaluation of ^(18)F-FDG-SPECT/CT imaging in diagnosis and staging of patients with suspected lung cancer

作　　者：阮征[1] 郑健[1] 黄海龙[1] 张闻瑞[2] 赵晋华[2] 

机构地区：[1]上海市第一人民医院胸外科,200085 [2]上海市第一人民医院核医学科,200085

出　　处：《中国肺癌杂志》2005年第2期120-123,共4页Chinese Journal of Lung Cancer

摘　　要：背景与目的　正确的诊断对肺癌疑似患者是至关重要的。根据肿瘤组织摄取18 F FDG的能力远大于正常组织的原理,本研究探讨了双探头符合线路SPECT/CT在肺癌诊断中的临床应用价值。方法　对61例肺部肿块患者进行18F FDG SPECT/CT检查,对良恶性肿块的摄取比值R进行比较,并与CT检查和病理检查结果进行比较。结果　以摄取比值R≥2 为标准,18 F FDG SPECT/CT对肺癌诊断的敏感性为82%,特异度为87%,准确率为84%。18 F FDG SPECT/CT对纵隔淋巴结转移的诊断与病理结果的符合率为81%,而CT诊断与病理结果的符合率为52%,二者有显著性差异(P<0.05)。结论　18 F FDG SPECT/CT对肺癌的诊断与鉴别诊断以及临床分期有重要的应用价值。Background and objective Correct diagnosis is very important to patients with suspected lung cancer. According to the higher 18 F-FDG intake of tumor tissues much more than normal tissues, this study evaluates the clinical value of 18 F-FDG dual-head coincidence SPECT/CT in diagnosis of lung cancer. Methods Sixty-one patients with lung mass underwent 18 F-FDG dual-head coincidence SPECT/CT imaging and thoracic CT imaging before operation. These imageological results were compared with histological examination of lung mass. Results The sensitivity, specificity and accuracy of 18 F-FDG-SPECT/CT in differentiating malignant and benign lesions were 82%, 87%, 84%, respectively. Compared with thoracic CT imaging, diagnostic rate of mediastinal lymphatic metastasis was significantly higher by 18 F-FDG-SPECT/CT (52% vs 81%, P< 0.05) . Conclusion Combined functional-anatomical image of 18 F-FDG-SPECT/CT has potential to improve staging and localizing procedures of lung cancer. It is an excellent modality in diagnosis and differential diagnosis of lung cancer.

关 键 词：肺肿瘤 诊断 18-氟脱氧葡萄糖 双探头符合线路显像 

分 类 号：R734.2[医药卫生—肿瘤]