山羊下颌骨牵张成骨术的实验研究  

Mandibular Distraction Osteogenesis: an Experimental Study in Goats

作　　者：郑晓辉[1] 田卫东[1] 龙洁[1] 敬伟[1] 李声伟[1] 

机构地区：[1]四川大学华西口腔医学院口腔颌面外科学教研室,成都610041

出　　处：《四川大学学报（医学版）》2005年第3期386-389,共4页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金 (批准号 3 0 0 70 819);四川省应用基础研究计划 (0 3 JY0 2 9-0 88-1)资助

摘　　要：目的　明确牵张成骨的骨形成过程及机制,为进一步的深入研究奠定实验基础。方法　选取8只3月龄健康幼年山羊,建立下颌骨牵张成骨术的实验动物模型,成模后动物随机分为4组,每组2只,第1组动物在牵张完成后1周处死,第2组在牵张完成后2周处死,第3组在牵张完成后4周处死,第4组在牵张完成后6周处死。对新生骨的组织学、影像学及骨密度的变化进行观察。结果　所有动物的右下颌骨均延长了大约10 mm ,组织学证实牵张区确有新骨形成。随着固定期时间的延长,X线检查和骨密度测试结果显示新骨组织中骨密度逐渐增高。牵张器相接触一侧的新生骨的骨质成骨较差。结论　山羊是一种较理想的对牵张成骨进行模拟性研究的实验动物,采用与牵张方向一致的牵张器施力方向可以避免侧向力的产生,从而提高术后成骨质量。Objective This experiment was designed to develop an experimental model of mandibular distraction osteogenesis in goats for determining the principle and the process of distraction osteogenesis. Methods Eight 3-month-old, healthy domestic goats were randomly divided into four groups (n=2 per group). The animals from each group were killed at 1, 2, 4, and 6 weeks after bone distraction, respectively. The sections of newly formed bone were obtained and evaluated with histologic and radiographic study. We also assessed the newly formed bone with bone density examination. Results The specimens of right mandible increased averagely 10 mm after distraction. The Newly formed bone was demonstrated histologically. The X-ray examination and bone density measurements showed that the bone density increased with the time of fixation. Conclusion Goat is a proper experimental animal for modeling mandibular distraction osteogenesis, and in this regal, it is important to keep the direction of distracter force in conformity with the direction of the expected distraction osteogenesis for avoiding the side force and thus ensuring successful distraction and good quality of newly formed bone.

关 键 词：下颌骨 牵张成骨术 骨密度 

分 类 号：R782.2[医药卫生—口腔医学]