应激相关的热休克信号转导通路的研究进展  

Progress in stress-induced heat shock signaling pathways

作　　者：李煜生[1] 姜勇[1] 

机构地区：[1]南方医科大学病理生理学教研室和广东省功能蛋白质组学重点实验室,广东广州510515

出　　处：《中国病理生理杂志》2005年第5期1030-1035,共6页Chinese Journal of Pathophysiology

基　　金：国家杰出青年科学基金资助项目(No.39925014);国家自然科学基金资助项目(No.30030060);重大基础理论研究(973)计划项目(No.2002CB513000);国家高技术研究发展计划(863)课题(No.2001AA234061)

摘　　要：LI Yu-sheng, JIANG Yong (Department of Pathophysiology and Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University, Guangzhou 510515, China) abtract:A lot of diseases (e.g., acute infarction and infections) and the diversity of harmful environmental changes, including elevating temperature, heavy metals and oxidants damage many kinds of proteins in organism. The denatured proteins usually evoke endogenous adaptive cellular mechanisms called heat shock response. After the activation, heat shock factors (HSFs) bind with heat shock element (HSE). This progress induces heat shock protein (HSP) expression, then facilitates repair of misfolded proteins, and finally inhibits the cell death (both necrosis and apoptosis) pathways. This review will introduce the structures and functions of HSF, HSP and HSE and details on the signaling process of HSP regulation by HSF.LI Yu-sheng, JIANG Yong (Department of Pathophysiology and Key Laboratory of Functional Proteomics of Guangdong Province, Southern Medical University, Guangzhou 510515, China) abtract:A lot of diseases (e.g., acute infarction and infections) and the diversity of harmful environmental changes, including elevating temperature, heavy metals and oxidants damage many kinds of proteins in organism. The denatured proteins usually evoke endogenous adaptive cellular mechanisms called heat shock response. After the activation, heat shock factors (HSFs) bind with heat shock element (HSE). This progress induces heat shock protein (HSP) expression, then facilitates repair of misfolded proteins, and finally inhibits the cell death (both necrosis and apoptosis) pathways. This review will introduce the structures and functions of HSF, HSP and HSE and details on the signaling process of HSP regulation by HSF.

关 键 词：热休克因子 热休克元件 热休克蛋白质类 信号转导 

分 类 号：R363[医药卫生—病理学]