半胱天冬酶天然抑制剂与细胞凋亡  

Natural inhibitors of caspases and cell apoptosis

作　　者：孙建义[1] 井明艳[1] 

机构地区：[1]浙江大学动物分子营养学教育部重点实验室,浙江杭州310029

出　　处：《中国病理生理杂志》2005年第5期1036-1040,共5页Chinese Journal of Pathophysiology

摘　　要：The crucial role of cell death in many diseases is obvious and has intense researches to understand the regulation of apoptotic pathways. Caspase activation is central to many of the apoptotic pathways. In recent years, the research on the regulation and activation of caspase has made a great progress. Caspase inhibitors prevent active caspases from committing the cell to irreversible destruction. This review will mainly focus on the characteristics of natural anticaspase inhibitor-IAP, regulation of IAP expression, mechanisms of action of IAP.The crucial role of cell death in many diseases is obvious and has intense researches to understand the regulation of apoptotic pathways. Caspase activation is central to many of the apoptotic pathways. In recent years, the research on the regulation and activation of caspase has made a great progress. Caspase inhibitors prevent active caspases from committing the cell to irreversible destruction. This review will mainly focus on the characteristics of natural anticaspase inhibitor-IAP, regulation of IAP expression, mechanisms of action of IAP.

关 键 词：半胱氨酸天冬氨酸蛋白酶 细胞凋亡 

分 类 号：R363[医药卫生—病理学]