脱细胞异体真皮基质修复口腔黏膜缺损的临床研究  

The clinical application of acellular dermal matrix to repair the defect of oral mucosa

作　　者：张伟[1] 胡敏[2] 王恩博[1] 布静秋[2] 

机构地区：[1]北京大学口腔医学院口腔颌面外科,100081 [2]解放军总医院口腔科

出　　处：《中华口腔医学杂志》2005年第3期241-243,共3页Chinese Journal of Stomatology

摘　　要：目的评价脱细胞异体真皮基质口腔黏膜补片修复口腔黏膜缺损的临床效果。方法采用脱细胞异体真皮修复42例浅表的口腔黏膜缺损,缺损部位为前庭沟、舌、口底、颊部、腭部、牙龈及唇部,缺损面积2.25～12.00cm2。将脱细胞真皮基质基底膜面向外,分别用缝线固定、反包扎、基托固定的方式,覆盖于黏膜缺损区。术后随访3个月～1年。结果完全成活40例,大部成活2例,无失败病例。脱细胞异体真皮存在两种成活形式,其中上皮化愈着成活12例,附着成活30例。术后收缩发生在2～4周,4周内收缩率为3.7%±1.1%。3个月后基本稳定。无瘢痕挛缩。结论脱细胞异体真皮可以作为自体皮片的替代品,取得满意的口腔黏膜修复效果。Objective To evaluate the clinical effect of acellular dermal matrix allograft in repairing the defect of oral mucosa. Methods Forty-two cases of large superficial defects in oral cavity were repaired by acellular dermal matrix. Defect areas included vestibule, tongue, the floor of mouth, buccal mucosa, palate, gingival and lip. Defect size was between 2.25 cm2 and 12 cm2. The basement membrane side of acellular dermal matrix was exposed to oral cavity, and another side was attached to the surgical wound surface. It was fixed by suture, reverse strapping and prepared template to overlaid large superficial defect of oral mucosa. The patients were followed up from 3 months to 1 year after operation. Results The wounds were completely healed in 40 cases, partially healed in 2 cases. There was no failure case. The healing was divided into two types: epithelialization healing pattern in 12 cases, attached healing pattern in 30 cases. Contraction of grafts occurred at 2-4 weeks. The contraction rate was 3.7%±1.1% at fourth week. Scarring did not appear. Conclusion The clinical result of acellular dermal matrix allograft in repair the defect of oral mucosa is good. Acellular dermal matrix can be taken as a substitute to autograft of skin.

关 键 词：脱细胞异体真皮基质 口腔黏膜 临床研究 脱细胞真皮基质 临床效果 补片修复 缺损部位 缝线固定 术后随访 失败病例 瘢痕挛缩 自体皮片 修复效果 成活 基底膜 上皮化 后收缩 收缩率 替代品 

分 类 号：R782.2[医药卫生—口腔医学]