肺癌患者血清与支气管肺泡灌洗液和胸腔积液中TPS水平检测及其临床意义的研究  

Study on the levels of the TPS in serum,pleural effusion and BALF and their clinical significance in patients with lung cancer

作　　者：李雅莉[1] 赵立群[2] 张娟妮 任晓肖[1] 张洁[1] 杨德昌[1] 

机构地区：[1]西安交通大学第二医院呼吸内科,陕西西安710004 [2]西安第四医院呼吸内科,陕西西安710004 [3]陕西高等医学专科学校临床系,陕西西安710068

出　　处：《肿瘤防治杂志》2005年第6期453-455,共3页China Journal of Cancer Prevention and Treatment

摘　　要：目的检测肺癌患者血清与胸腔积液和支气管肺泡灌液(BALF)中组织多肽特异性抗原(TPS)水平,判断其对肺癌的早期诊断、分期、分型的临床价值。方法采用酶联免疫吸附分析法(ELISA)法测定65例肺癌患者及54例良性肺病患者血清与胸腔积液及BALF中TPS的水平。结果肺癌患者TPS水平明显高于对照组患者(P=0.02);肺癌组胸腔积液中TPS水平较高;非小细胞癌的TPS水平高于小细胞肺癌组;Ⅲ期和Ⅳ期的TPS水平高于Ⅰ期和Ⅱ期的。结论TPS可用于肺良、恶性疾病的鉴别。胸腔积液与血清中的TPS水平比较稳定,能够真实的反映肿瘤的分化、表达情况,可用于鉴别小细胞肺癌和非小细胞肺癌。OBJECTIVE: This research detected tissue p ol ypeptide specificantigen (TPS)of serum, pleural effusion and BALF in lung cancer patients, according to the level of TPS, we can judge its clinical value to dia ngosea primary patients and to examine the histological typing and clinical peri od. METHODS: TPS was determined using enzyme immunoassay t echniques, we detected the TPS in 65 patients with lung cancer and compared with a group of 54 patients with some form of non-neoplastic pulmonary disease (NNP D). RESULTS: 1) The level of TPS of serum in lung cancer g roup is obvious higher than the matched control (P<0.05); 2) In lung cancer group, the level of TPS in Pleural effusion is higher than serum and BALF; 3)Th e level of TPS in the NSCLC is higher than SCLC group; 4) The level of TPS in Ⅲ and Ⅳ period is higher thanⅠand Ⅱ period. CONSLUSION: 1)The TPS can identify the lung cancer from other lung disease. 2) The level of TPS in the serum and Pleural effusion is very stable, and can truely reflect the differentiation and and express of tumor. 3)TPS of serum and Pleural effusion c an distinguish NSCLC between SCLC.[

关 键 词：肺肿瘤 组织多肽特异性抗原(TPS) 血清 胸腔积液 支气管肺泡灌洗液 

分 类 号：R734.2[医药卫生—肿瘤]