奈西雅预防治疗化疗所致胃肠道反应的临床研究  

Efficacy of nasea injection in prevention and treatment of gastrointestinal reaction induced by chemotherapy

作　　者：张红军[1] 邱文生[1] 

机构地区：[1]青岛大学医学院附属医院肿瘤科,山东青岛266003

出　　处：《肿瘤防治杂志》2005年第9期696-698,共3页China Journal of Cancer Prevention and Treatment

摘　　要：目的:观察奈西雅防治化疗药物引起的胃肠道反应的疗效及其不良反应.方法:采用开放式的研究,对86例患者化疗同时给予奈西雅(0.3 mg,静脉推注,d1～d3),观察化疗不同时间其对食欲不振、恶心、呕吐等的预防和治疗作用.结果:奈西雅防治化疗药物尤其是顺铂和(或)表阿霉素的胃肠道不良反应有较好疗效,有效率分别为53.5%～90.6%;对顺铂引起的迟发性呕吐亦有一定的防治作用;不良反应轻,主要为便秘、头痛、口干、头重、发热感等.结论:奈西雅能有效防治化疗药物所致的胃肠道反应,疗效维持时间长,不良反应轻,为较好的化疗止吐剂.OBJECTIVE:To evaluate the efficacy and toxicity of Nasea in the prevention and treatment of gastrointestinal reaction induced by chemotherapy. METHODS: The study was an open clinical trial. Eighty-six patients received the injection of nasea while chemotherapy. The efficacy and side effects of nasea were evaluated at the same time. RESULTS: Nasea was effective in the control of anorexia, nausea and vomiting induced by anti-cancer drugs(especially for DDP and EPI ), the response rates were 53.5%-90.6% respectively. The side effects of nasea were constipation, headache, thirst feeling, head heaviness, fever feeling, etc. All of them were mild. CONCLUSIONS: Nasea can effectively prevent and treat the gastrointestinal reaction induced by chemotherapeutic agents. [

关 键 词：癌/药物疗法 药物疗法/副作用 胃肠活动/药物疗法 

分 类 号：R730.53[医药卫生—肿瘤]