p57^(kip2)、Cyclin E在脑胶质瘤中的表达及临床意义  

Expression of p57^(kip2) and Cyclin E Protein in Human Glioma and its Clinical Significances

作　　者：吴斌[1] 袁先厚[1] 江普查[1] 文志华[1] 

机构地区：[1]武汉大学中南医院神经外科,430071

出　　处：《肿瘤防治研究》2005年第5期260-262,共3页Cancer Research on Prevention and Treatment

摘　　要：目的探讨p57kip2蛋白、CyclinE蛋白在人脑胶质瘤表达情况及其临床意义。方法采用免疫组织化学SP法检测p57kip2、CyclinE在46例胶质瘤和10例正常脑组织中的表达。结果在46例胶质瘤中,p57kip2蛋白阳性率为34.8%(16/46),显著低于正常脑组织(70%)(P<0.05)。低度恶性(Ⅰ～Ⅱ)、高度恶性(Ⅲ～Ⅳ级)及两年生存时间组别间差异有显著性(P<0.01)。CyclinE蛋白阳性率为58.6%(27/46),显著高于正常脑组织(20%)(P<0.05)。脑胶质瘤不同恶性程度及两年生存时间组别间差异有显著性(P<0.05)。p57kip2蛋白的表达与CyclinE蛋白的表达密切相关(rs=-0.359)。结论p57kip2蛋白和CyclinE蛋白在脑胶质瘤的发生、发展中起重要作用。且与肿瘤的分化程度、患者预后密切相关。Objective To explore the expression of p57 kip2、Cyclin E in human gliomas and its clinical significances. Methods The expression of p57 kip2 and Cyclin E proteins in human glioma tissues in 46 patients was detected by SP immunohistochemical technique. Results The p57 kip2protein positive-expression rate in human glioma was 34.8%, which was lower than that in normal brain tissue (P < 0.05). The p57 kip2 protein positive-expression correlated significantly with clinicopathologic grade (P < 0.05)and the two-year survival time (P > 0.01) . The Cyclin E positive-expression rate in human glioma was 58.6%.The Cyclin E positive-expression also correlated significantly with clinicopathologic grade (P < 0.05) and the two-year survival time (P < 0.05).There were significant correlation with the expression of p57 kip2 protein and Cyclin E protein (r s = -0.359, P < 0.05). Conclusion The expression of p57 kip2 protein and Cyclin E protein plays an important role in the development of glioma .They also correlated significantly with the differentiation degree of human gliomas and Prognosis.

关 键 词：P57^KIP2蛋白 CYCLINE蛋白 脑胶质瘤 免疫组织化学技术 

分 类 号：R739.41[医药卫生—肿瘤]