乳腺癌钼靶X线表现与P53基因的关系  

Correlativie Study on Mammographic Features and P53 Gene of Breast Cancer

作　　者：马捷[1] 左敏[2] 孙国平[1] 臧达[1] 王晓玫[2] 徐坚民[1] 

机构地区：[1]广东省深圳市人民医院放射科,1516020 [2]广东省深圳市人民医院病理科,1516020

出　　处：《中国医学影像学杂志》2005年第3期172-175,共4页Chinese Journal of Medical Imaging

基　　金：深圳市科技局资助课题;编号 ( 2 0 0 4 0 4 0 2 5 )

摘　　要：目的:探讨乳腺癌钼靶X线表现与P53癌基因表达之间的关系。材料和方法:将71例乳腺癌X线征象中钙化、毛刺、病变密度、是否同时合并乳腺囊性增生症与经免疫组织化学染色测定P53基因的表达进行对照研究。结果:71例乳腺癌中,钙化4 0例,占56 . 3% ;毛刺征2 3例,占32 .4 % ;病变区表现为高密度38例,占53. 5% ;乳腺癌同时合并乳腺囊性增生症4 6例,占6 4 .8%。P53基因表达阳性4 0例,占56 . 3%。结论:乳腺癌钼靶X线征象在一定程度上反映了P53基因表达状态。Purpose: To investigate the correlation between the molbdemum target mammographic features and P53 gene of breast cancer. Materials and Methods: The mammographic features of 71 patients with breast carcinoma, including calcificatin, spicule, density, breast cysitic hyperplasia accompainied, were studied comparatively with P53 gene stained with immunohistochemical technique. Results: Of 71 cases, the calcification was in 40 cases (56.34%), spicule sign in 23 cases (32.39%), hyperdensity in 38 case (53.52%), and breast cysitic hyperplasia of the breast carcinomas in 46 cases (64.79%). The expsession status of P53 gene was positive in 40 cases (56.3%). Conclusion: The molybdenum target mammographic features of breast cancer can reflect the expression status of P53 gene.

关 键 词：钼靶X线表现 乳腺癌 乳腺囊性增生症 P53基因表达 免疫组织化学染色 癌基因表达 X线征象 病变密度 对照研究 X线征象 毛刺征 钙化 

分 类 号：R737.9[医药卫生—肿瘤] R655.8[医药卫生—临床医学]