机构地区:[1]桂林医学院物理教研室,广西省桂林市541004 [2]桂林市第二人民医院内科,广西省桂林市541001 [3]复旦大学生物力学教研室,上海市200032 [4]大连医科大学物理教研室,辽宁省大连市116027
出 处:《中国临床康复》2005年第15期192-193,共2页Chinese Journal of Clinical Rehabilitation
基 金:广西教育厅科研项目(200135)~~
摘 要:背景:全血黏度是血液流变学研究的重点,对于揭示因血液流变性改变而出现的心肌梗死、脑梗死等缺血性疾病的发生具有重要意义。目的:研究血液的宏观与微观流变学特征,探寻血液流变学测量方法的标准化。设计:以健康体检者的静脉血为纳入对象的对比实验。单位:桂林医学院物理教研室。材料:随机选取86例健康体检者的静脉血于桂林医学院血液流变学研究室完成实验。方法:本实验86例全血样品,在7个剪变率(0.6,2,5,10,20,40,100s-1)下,顺序从低剪变率到高剪变率,再从高剪变率到低剪变率进行检测,对两个过程的测量值进行比较。主要观察指标:①主要结局:两个测量过程7个剪变率下的表观黏度值。②次要结局:两个测量过程下的Casson黏度、屈服应力。结果:两个测量过程,同一剪变率下的表观黏度值,除0.6s-1对应的表观黏度值有显著性差异外(P<0.05),其余各表观黏度值无显差异(P>0.5),Casson黏度和屈服应力值无显著性差异(P>0.5,P>0.3)。结论:实验研究中测量Casson黏度、屈服应力值有利于优化血液流变学检测指标和测量方法的标准化,且对同一血样重复测试表观黏度、Cas-son黏度和屈服应力值是可行的。对于揭示血液流变性的改变,以及心肌梗死、脑梗死、高血压、冠心病等缺血性疾病的发生和发展机理具有重要意义。BACKGROUND:Whole blood viscosity is the keystone in hemorheological research,which has important significance in the exposure of the generation of ischemic diseases including myocardial infarction (MI) and cerebral infarction(CI) due to hemorheological changes. OBJECTIVE:To investigate the characters of macroscopical and microscopical hemorheology to explore the standardization of hemorheological measuring method. DESIGN:An observatory comparative study based on the venous blood of healthy individual. SETTING:Department of physics in a medical college. MATERIALS:Venous bloods of 86 healthy individuals were randomly selected for the study, which was conducted in the Laboratory of Hemorheology of Guilin Medical College. METHODS:Totally 86 whole blood samples were tested under 7 shear rates(0.6 s-1,2 s-1,5 s-1,10 s-1,20 s-1,40 s-1, 100 s-1) from low shear rate to high shear rate, and then from high shear rate to low shear rate.The measuring value of the two processes was compared. MAIN OUTCOME MEASURES:①Major consequence:apparent viscosity under 7 shear rates in two measuring process;②Minor consequence:Casson viscosity and yield stress in two measuring process. RESULTS:There was no significant difference of apparent viscosity(P >0.05) except the 0.6 s-1 -corresponding apparent viscosity (P< 0.05) at some shear rate in two measuring process.There was no significant difference in Casson viscosity and yield stress(P >0.5,P >0.3). CONCLUSION: The measurement of Casson viscosity and yield stress is good for the optimization of the standardization of hemorheological indicators and measuring method;and it is feasible to test apparent viscosity,Casson viscosity and yield stress repeatedly in same blood sample,which has important significance in the exposure of the hemorheological changes and the generation and development mechanism of ischemic diseases including MI,CI,hypertension, and coronary heart disease(CHD).
关 键 词:血液流变学 表观黏度 屈服应力 血液流变性改变 缺血性疾病 健康体检者 桂林医学院 显著性差异 心肌梗死 重要意义 测量方法 剪变率 流变学特征 宏观与微观 全血黏度 对比实验 全血样品 观察指标 实验研究 检测指标 重复测试
分 类 号:R743.33[医药卫生—神经病学与精神病学] R331.1[医药卫生—临床医学]
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